469911-86-2Relevant academic research and scientific papers
Carbon-13 and carbon-14 labeled dabigatran etexilate and tritium labeled dabigatran
Latli, Bachir,Kiesling, Ralf,A?falg, Stefan,Chevliakov, Max,Hrapchak, Matt,Campbell, Scot,Gonnella, Nina,Busacca, Carl A.,Senanayake, Chris H.
, p. 648 - 656 (2016)
Dabigatran etexilate or pradaxa, a novel oral anticoagulant, is a reversible, competitive, direct thrombin inhibitor. It is used to prevent strokes in patients with atrial fibrillation and the formation of blood clots in the veins (deep venous thrombosis) in adults who have had an operation to replace a hip or a knee. Pradaxa is the only novel oral anticoagulant available with both proven superiority to warfarin and a specific reversal agent for use in rare emergency situations. The detailed description of the synthesis of carbon-13 and carbon-14 labeled dabigatran etexilate, and tritium labeled dabigatran is described. The synthesis of carbon-13 dabigatran etexilate was accomplished in eight steps and in 6% overall yield starting from aniline-13C6. Ethyl bromoacetate-1-14C was the reagent of choice in the synthesis of carbon-14 labeled dabigatran etexilate in six steps and 17% overall yield. Tritium labeled dabigatran was prepared using either direct tritium incorporation under Crabtree's catalytic conditions or tritium-dehalogenation of a diiodo-precursor of dabigatran.
COMPOUND AND ORGANIC LIGHT EMITTING ELEMENT COMPRISING SAME
-
Paragraph 0132-0134, (2020/07/23)
Provided are a compound of Chemical Formula 1: wherein X1 to X4 are identical to or different from one another and are each independently O, S, NR2 or CR3R4, and a to d are each 0 or 1, with the proviso that 1≤a+b+c+d; R1 and R11 to R14 are identical to o
Preparation of Polyfunctional Heterocycles Using Highly Functionalized Aminated Arylmagnesium Reagents as Versatile Scaffolds
Lindsay, David M.,Dohle, Wolfgang,Jensen, Anne Eeg,Kopp, Felix,Knochel, Paul
, p. 1819 - 1822 (2007/10/03)
(Equation Presented) Functionalized Grignard reagents, derived from readily available o-iodoaniline derivatives and obtained via a straightforward iodine-magnesium exchange, can be used to prepare a wide range of polyfunctional indoles, quinolines, and quinazolinones.
