470455-95-9

Upstream product

• 470455-86-8 2-[5-acetyl-3-cyano-4-(4-methoxy-phenyl)-6-methyl-pyridin-2-ylsulfanyl]-acetamide 
• 121104-38-9 5-acetyl-3-cyano-4-(4-methoxyphenyl)-6-methylpyridine-2(1H)-thione 
• 647828-97-5 8-acetyl-2,7-dimethyl-9-(4'-methoxyphenyl)pyrido[3',2':4,5]thieno[3,2-d][1,3]-oxazin-4-one 
• 108-24-7 acetic anhydride 
• 380638-21-1 AE-641/15124054 
• 647828-96-4 5-acetyl-3-amino-4-(4'-methoxyphenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid 
• 647828-89-5 [5-acetyl-3-cyano-4-(4-methoxy-phenyl)-6-methyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester 
• 233276-72-7 5-acetyl-3-amino-4-(4-methoxy-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 

Downstream Products

• 470456-11-2 [8-Acetyl-9-(4-methoxy-phenyl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-ylsulfanyl]-acetic acid ethyl ester 
• 470456-20-3 1-[4-(3,5-Dimethyl-pyrazol-1-yl)-9-(4-methoxy-phenyl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone 
• 470456-14-5 1-[4-Hydrazino-9-(4-methoxy-phenyl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone 
• 470456-06-5 1-[9-(4-Methoxy-phenyl)-2,7-dimethyl-4-thioxo-3,4-dihydro-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone 
• 470456-01-0 1-[4-Chloro-9-(4-methoxy-phenyl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone 

Relevant academic research and scientific papers

Synthesis of New Thienopyridines, Pyridothienopyrimidines and Pyranothienopyridines with Anticipated Biological Activity

5-Acetyl-4-aryl-3-cyano-6-methylpyridine-2(1H)-thiones (1a,b) were reacted with ethyl chloroacetate to give ethyl 5-acetyl-4-aryl-3-cyano-6-methylpyridin-2-ylthio) acetates (2a,2b) which, in turn, underwent intramolecular Thorpe-Ziegler cyclization to furnish ethyl 5-acetyl-3-amino-4-aryl-6-methylthieno[2,3-b]pyridine-2-carboxylates (3a,b). The reaction of esters 2a,b with hydrazine hydrate in refluxing ethanol produced (5-acetyl-4-aryl-3-cyano-6-methylpyridin-2-ylthio)acethydrazides (4a,b). When the latter reaction was performed under neat conditions, the products were identified as 5-acetyl-3-amino-4-aryl-6-methylthieno[2,3-b]pyridine-2-carbohydrazides (5a,b). Saponification of o-aminoester 3a gave the corresponding acid 13. The compounds 4a,b,5a,b and 13 were used as key intermediates in the synthesis of the target compounds.

Synthesis and antimicrobial activity of new pyridothienopyrimidines and pyridothienotriazines

5-Acetyl-3-amino-4-aryl-6-methylthieno[2,3-b]pyridine-2-carboxamides (5a,b) were reacted with triethyl orthoformate or nitrous acid to give the corresponding pyrimidinones 6a,b and triazinones 7a,b. The reaction of 5a,b with acetic anhydride was carried o