470465-28-2

Upstream product

• 55218-06-9 1,2,6-trimethoxynaphthalene 
• 470465-19-1 (4S,5S,3'S)-3'-((Z)-3-Bromo-2-methyl-allyl)-5',6'-dimethoxy-4,5-diphenyl-3',4'-dihydro-1'H-spiro[[1,3]dioxolane-2,2'-naphthalene] 
• 470465-25-9 N-(2-bromo-ethyl)-N-[4-formyl-5,6-dimethoxy-3-(2-oxo-propyl)-1,2,3,4-tetrahydro-naphthalen-2-yl]-benzenesulfonamide 
• 470465-20-4 C₃₀H₃₀O₄ 
• 470465-24-8 N-(2-bromo-ethyl)-N-(8,9-dimethoxy-2-methyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[a]naphthalen-4-yl)-benzenesulfonamide 
• 470465-23-7 N-(8,9-dimethoxy-2-methyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[a]naphthalen-4-yl)-benzenesulfonamide 
• 470465-21-5 (3aR,9bS)-8,9-Dimethoxy-2-methyl-3,3a,5,9b-tetrahydro-cyclopenta[a]naphthalen-4-one 
• 470465-34-0 5,6-dimethoxy-2-oxo-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid methyl ester 
• 470465-18-0 3-(3-bromo-2-methyl-allyl)-5,6-dimethoxy-3,4-dihydro-1H-naphthalen-2-one 
• 470465-22-6 8,9-dimethoxy-2-methyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[a]naphthalen-4-ol 
• 66996-59-6 1,6-dibromo-2-methoxynaphthalene 
• 16239-18-2 1,6-dibromo-2-naphthol 
• 52644-01-6 5,6-dimethoxy-2-tetralone 

Downstream Products

• 76-57-3 codeine 
• 57-27-2 MORPHIN 
• 470465-31-7 C₂₆H₂₉NO₅Se 

Relevant academic research and scientific papers

Synthesis of (-)-morphine

The preparation of the diastereomerically pure β-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was converted over several steps to (-)-morphine 1. Copyright