470480-22-9Relevant academic research and scientific papers
Copper-Catalyzed [2 + 3] Cyclization of α-Hydroxyl Ketones and Arylacetonitriles: Access to Multisubstituted Butenolides and Oxazoles
Qi, Chaorong,Peng, Youbin,Wang, Lu,Ren, Yanwei,Jiang, Huanfeng
, p. 11926 - 11935 (2018/09/25)
A copper-catalyzed [2 + 3] formal cyclization reaction between α-hydroxyl ketones and arylacetonitriles has been developed. The reaction outcome was ultimately dependent on the structure of the α-hydroxy ketones employed. Tertiary α-hydroxy ketones gave 3,4,5,5-tetrasubstituted butenolides as the sole products, while secondary α-hydroxy ketones furnished 2,4,5-trisubstituted oxazoles selectively. This method has many advantages, such as the use of easily available substrates, broad substrate scope, good functional tolerance, and milder reaction conditions.
A facile approach to spirocyclic butenolides through cascade cyclization/oxidative cleavage reactions of (Z)-enynols catalyzed by gold under dioxygen atmosphere
Song, Feijie,Liu, Yuanhong
experimental part, p. 502 - 509 (2009/06/06)
A facile approach for the syntheses of spirocyclic butenolides through cascade cyclization/oxidative cleavage reactions of (Z)-enynols bearing cyclic substituents at the C-1 position catalyzed by gold under dioxygen atmosphere has been developed. A variet
