4705-14-0

Usage

Uses

Used in Pharmaceutical Industry:
N-methylidenecyclohexanamine is used as an intermediate in the synthesis of pharmaceuticals for its potential pharmacological effects and interaction with the central nervous system.
Used in Organic Compounds Synthesis:
N-methylidenecyclohexanamine is used as an intermediate in the synthesis of organic compounds due to its chemical properties.
Used in Research and Development:
N-methylidenecyclohexanamine is used as a subject of research into its potential use as a treatment for various neurological and psychiatric disorders, as well as its potential as an anti-convulsant.
Used in Regulatory Compliance:
N-methylidenecyclohexanamine is used in the regulation of its use and distribution in many countries due to its potential for abuse and addiction.

Upstream product

• 50-00-0 formaldehyd 
• 19573-22-9 cyclohexyl azide 
• 811-98-3 d⁽⁴⁾-methanol 
• 6281-14-7 1,3,5-tricyclohexyl-[1,3,5]triazinane 

Downstream Products

• 1212-29-9 1,3-dicyclohexylthiourea 
• 17799-67-6 3-cyclohexyl-2,3-dihydro-4H-benzo[e][1,3]oxazin-4-one 
• 134126-45-7 C₉H₁₂Cl₃NO 
• 134126-49-1 4,5-bis(dichloromethylene)-1,3-dicyclohexylimidazolidin-2-one 
• 80283-98-3 C₂₀H₃₁N₂O₂PS₂ 
• 80283-97-2 C₁₈H₂₇N₂O₂PS₂ 
• 92667-42-0 N-Acetoxymethyl-N-nitrosocyclohexylamin 
• 92691-18-4 N-<(Nitrobenzoyloxy)methyl>-N-nitrosocyclohexylamin 
• 114820-96-1 2-cyclohexyl-oxaziridine 
• 6281-14-7 1,3,5-tricyclohexyl-[1,3,5]triazinane 
• 1100817-32-0 C₁₃H₂₀N₂O₃ 
• 1349129-35-6 1-cyclohexyl-5-methyl-1H-imidazole-4-carbohydrazide 3-oxide 
• 1601483-93-5 (E)-methyl 2-(1,3-dicyclohexylimidazolidin-4-ylidene)acetate 
• 1601484-04-1 (E)-methyl 2-(3-cyclohexyl-1,5-diphenylimidazolidin-4-ylidene)acetate 

Relevant academic research and scientific papers

1,3,5-Trialkyl-hexahydro-1,3,5-triazines-N-methylenealkylamines equilibria. 1H NMR studies in solutions

The behavior of 1,3,5-trialkyl-1,3,5-hexahydrotriazines (A) in a variety of solvents was investigated by 1H NMR. A are stable for linear alkyls in deuterated solvents such as chloroform, benzene, acetone, dioxane, dimethylsulfoxide and acetonitrile. In case of branched alkyls, A are in equilibrium with N-methylenealkylamines (B). The A/B ratio depends on solvent, concentration of the sample and temperature. A react easily with methanol and lead to the formation of N-(methoxymethyl)amines (C), which are in equilibrium with B. Both the quantitative evaluation of A-B equilibrium in solutions as well as the formation of C in methanol was described for the first time.

Convenient procedure for one-pot conversion of azides to N-monomethylamines

One-pot conversion of azides to N-monomethylamines is described. Two optional protocols have been developed, which share the first stage, the reaction of an azide with (CH3)3P to generate the corresponding iminophosphorane. This Staudinger intermediate, thus generated, is either methylated with CH3I and hydrolyzed (method A), or treated with (HCHO)n and reduced with NaBH4 (method B), thereby giving the corresponding N-monomethylamine in high yield.