47070-20-2Relevant academic research and scientific papers
Crystal structure of thioflavin-T and its binding to amyloid fibrils: Insights at the molecular level
Rodriguez-Rodriguez, Cristina,Rimola, Albert,Rodriguez-Santiago, Luis,Ugliengo, Piero,Alvarez-Larena, Angel,Gutierrez-De-Teran, Hugo,Sodupe, Mariona,Gonzalez-Duarte, Pilar
, p. 1156 - 1158 (2010)
Combining X-ray data on thioflavin-T and theoretical calculations on its binding to a peptide model for Aβ1-42 fibrils gives evidence of main stabilizing interactions, which influence the dihedral angle between the two moieties of thioflavin-T and thereby its fluorescence properties; these results shed new light on possible strategies for the design of dyes to bind amyloid fibrils more specifically.
