470700-01-7

Upstream product

• 470699-86-6 6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine 
• 470699-88-8 5'-O-benzyl-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-{[(2-(2-iodophenyl)ethyl)thio]carbonyl}adenosine 
• 470699-87-7 5'-O-benzyl-6-N-(tert-butyloxycarbonyl)-4'α-carboxyl-2'-deoxyadenosine 
• 208175-48-8 5'-O-benzyl-6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-adenosine 
• 470699-90-2 5'-O-benzyl-6-N-(tert-butyloxycarbonyl)-2'-deoxy-3'-O-diethylphosphoryl-4'α-{[(2-(2-iodophenyl)ethyl)thio]carbonyl}adenosine 

Downstream Products

• 4565-32-6 2,3-dihydrobenzo(b)thiophene 

Relevant academic research and scientific papers

The effect of the base in the fragmentation of nucleotide C4′ radicals

A series of 3′-O-diethylphosphoryl-4′-α-[(2-halophenylethylthio) carbonyl] substituted esters of thymidine, cytidine, adenosine and guanosine are prepared by total synthesis and used as C4′-radical precursors in a competition kinetic method using tributyltin hydride as the reductant. The pseudo-first order rate constants for the C4′-radicals so generated decrease in the order guansoine>cytidine>adenosine>thymidine with that for guanosine being too rapid for determination by the present competition kinetic method. A 119Sn NMR method is presented for estimation of the purity of tin hydride solutions.