470713-29-2 Usage
Uses
Used in Pharmaceutical Research:
AKOS B015840 is used as a research chemical for studying its effects on the brain and behavior. It aids in understanding the mechanisms of action of psychoactive substances and their potential therapeutic applications.
Used in Neuroscientific Studies:
In the field of neuroscience, AKOS B015840 is used as a tool to investigate the neural pathways and receptors involved in the psychoactive effects of similar compounds. This research can contribute to the development of new treatments for neurological and psychiatric disorders.
Used in Toxicological Research:
AKOS B015840 is employed in toxicological studies to assess the safety and potential risks associated with its use. This research is vital for establishing guidelines and protocols for handling and administering the compound in both research and clinical settings.
Used in Drug Development:
Although its mechanisms of action are not yet fully understood, AKOS B015840 may have potential applications in drug development. Further research could reveal its therapeutic potential for various conditions, leading to the creation of new medications.
Used in Forensic Analysis:
In forensic science, AKOS B015840 may be used as a reference compound for identifying and analyzing similar psychoactive substances found in criminal investigations. This can help in understanding the prevalence and impact of these substances in society.
Check Digit Verification of cas no
The CAS Registry Mumber 470713-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,0,7,1 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 470713-29:
(8*4)+(7*7)+(6*0)+(5*7)+(4*1)+(3*3)+(2*2)+(1*9)=142
142 % 10 = 2
So 470713-29-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H4ClNOS3/c9-6-2-1-4(13-6)3-5-7(11)10-8(12)14-5/h1-3H,(H,10,11,12)/b5-3-
470713-29-2Relevant academic research and scientific papers
Privileged scaffolds or promiscuous binders: A comparative study on rhodanines and related heterocycles in medicinal chemistry
Mendgen, Thomas,Steuer, Christian,Klein, Christian D.
supporting information; experimental part, p. 743 - 753 (2012/03/11)
Rhodanines and related five-membered heterocycles with multiple heteroatoms have recently gained a reputation of being unselective compounds that appear as "frequent hitters" in screening campaigns and therefore have little value in drug discovery. However, this judgment appears to be based mostly on anecdotal evidence. Having identified various rhodanines and related compounds in screening campaigns, we decided to perform a systematic study on their promiscuity. An amount of 163 rhodanines, hydantoins, thiohydantoins, and thiazolidinediones were synthesized and tested against several targets. The compounds were also characterized with respect to aggregation and electrophilic reactivity, and the binding modes of rhodanines and related compounds in published X-ray cocrystal structures were analyzed. The results indicate that the exocyclic, double bonded sulfur atom in rhodanines and thiohydantoins, in addition to other structural features, offers a particularly high density of interaction sites for polar interactions and hydrogen bonds. This causes a promiscuous behavior at concentrations in the "screening range" but should not be regarded as a general knockout criterion that excludes such screening hits from further development. It is suggested that special criteria for target affinity and selectivity are applied to these classes of compounds and that their exceptional and potentially valuable biomolecular binding properties are consequently exploited in a useful way.
