4708-18-3Relevant academic research and scientific papers
Pd-free Sonogashira coupling: One pot synthesis of phthalide via domino Sonogashira coupling and 5-exo-dig cyclization
Dhara, Shubhendu,Singha, Raju,Ghosh, Munmun,Ahmed, Atiur,Nuree, Yasin,Das, Anuvab,Ray, Jayanta K.
, p. 42604 - 42607 (2014)
Phthalides have been synthesized exclusively in one pot via Pd-free Sonogashira coupling. A Cu-catalyzed domino Sonogashira coupling and 5-exo-dig cyclization between suitable substituted ortho-bromobenzoic acids and terminal alkynes afforded phthalides in good yields under mild reaction conditions.
