4714-37-8

Upstream product

• 17936-73-1 2,2,2-trichloro-1-p-tolyl-ethanol 
• 41747-39-1 p-tolyl(trichloromethyl)carbinol acetate 
• 104-87-0 4-methyl-benzaldehyde 
• 1620143-43-2 ethyl 2,2,2-trichloro-1-p-tolylethyl carbonate 
• 56-23-5 tetrachloromethane 
• 52693-87-5 4-methylbenzaldehyde hydrazone 

Downstream Products

• 699-02-5 4-Methylphenethyl alcohol 
• 99-94-5 p-Toluic acid 
• 33491-04-2 1-(chloroethynyl)-4-methylbenzene 
• 410536-78-6 N,N,N'-Trimethyl-N'-(p-tolylethinyl)hydrazin 
• 1187772-35-5 2-[(4-methylphenyl)ethynyl]benzoxazole 
• 1218811-78-9 2-[(4-methylphenyl)ethynyl]-5-[(4-trifluoromethyl)phenyl]oxazole 
• 41255-31-6 6-chloro-2-(p-tolyl)-4H-chromen-4-one 
• 108980-49-0 4'-Methyl-7-Methoxyflavone 
• 88952-74-3 6-methyl-2-(p-tolyl)-4H-chromen-4-one 
• 41255-30-5 4'-methylflavone 
• 1005500-78-6 N,4-dimethyl-N-(p-tolylethynyl)benzenesulfonamide 
• 2789-88-0 1,2-bis(4-methylphenyl)acetylene 
• 3287-02-3 4-(phenylethynyl)toluene 
• 64583-17-1 1-(4-fluorophenyl)-2-(4-methylphenyl)acetylene 

Relevant academic research and scientific papers

Efficient Multigram Approach to Acetylenes and CF3-ynones Starting from Dichloroalkenes Prepared by Catalytic Olefination Reaction (COR)

A novel approach to terminal acetylenes based on catalytic olefination reaction COR of arylaldehydes to form dichloroalkenes followed by treatment with nBuLi was elaborated. This method is atom economical and displays high yields and effectivity. The corresponding alkynes can be prepared in up to 97 % yield. One pot procedure towards CF3-ynones was elaborated to provide these products in up to 87 % yield starting from dichloroalkenes.

Stereodivergent Synthesis of Alkenylpyridines via Pd/Cu Catalyzed C-H Alkenylation of Pyridinium Salts with Alkynes

The first Pd/Cu catalyzed selective C2-alkenylation of pyridines with internal alkynes has been developed via the pyridinium salt activation strategy. Importantly, the configuration of the product alkenylpyridines could be tuned by the choice of the proper N-alkyl group of the pyridinium salts, thus allowing for both the Z- and E-alkenylpyridines synthesized with good regio- and stereoselectivity. A plausible mechanism was proposed based on the Hammett study and KIE experiment.

Cross-coupling reactivity of 1,1-dichloroalkenes under palladium catalysis: Domino synthesis of diarylalkynes

An efficient synthesis of diarylalkynes was achieved from the domino cross-coupling reaction of 1,1-dichloroalkenes with triarylbismuth reagents under palladium-catalyzed conditions. Under the established palladium protocol, 1,1-dichloroalkenes demonstrated hitherto unknown remarkable cross-coupling reactivity with organometallic triarylbismuth reagents to furnish functionalized diarylalkynes.

A Robust One-Step Approach to Ynamides

A robust one-step synthetic strategy for ynamide with cheap and easily available stock chemicals vinyl dichlorides and electron deficient amides as the starting material is described. In the absence of transition-metal catalyst, the reaction proceeds under mild reaction conditions in open air and thus rendering a convenient operation. This strategy is not only suitable for both terminal and internal ynamide synthesis but also amenable for large-scale preparation. Broad substrate scopes with respect to vinyl dichloride as well as electron-deficient amide were observed.

β-(Carbonatoxy)alkyl radicals: A new subset of β-(ester)alkyl radical fragmentation during copper(I)-mediated synthesis of 1,1-dichloro-1-alkenes

A new subset of β-(ester)alkyl radicals is presented. It is the first study on the chemistry of β-(alkoxycarbonyloxy)alkyl radicals that fill the gap in the spectrum of the migrating groups in β-(ester)alkyl radical reactions. The change from less nucleofugal (acetate) group to the more nucleofugal (carbonate) group in the spectrum of the migrating group changed the reaction path from rearrangement to fragmentation. This approach has been used for the synthesis of 1,1-dichloroalkenes in high yields. The formation of dichloroalkenes was accounted by the involvement of alkene radical cation and carbonate anion pair (a CIP) as a result of heterolysis of the CO bond of the carbonate at the β-position of the β-(alkoxycarbonyloxy)alkyl radical. The alkene radical cation was trapped by nucleophilic reaction with MeOH to form methyl ester.

SmI2-mediated elimination reaction of trichloromethyl carbinols: A facile method to synthesize vinyl dichlorides

Samarium diiodide-mediated elimination reaction provides a simple and general method to synthesize vinyl dichlorides from trichloromethyl carbinols directly in good to excellent yields.

Pyridazinone derivatives

The present invention provides a novel pyridazinone derivative represented by the formula wherein R is a hydrogen atom or methyl, X is a halogen atom, A is an oxygen atom or a sulfur atom, and X1 is a halogen atom; a insecticidal, miticidal and fungicidal composition for agricultural and horticultural use comprising an effective amount of said pyridazinone derivative; and method for killing harmful insects, mites and bacteria comprising applying to a plant an effective amount of said pyridazinone derivative.