471908-65-3Relevant academic research and scientific papers
Thioorthoesters in the activated Pictet-Spengler cyclization. Synthesis of 1-thiosubstituted tetrahydroisoquinolines and carbon-carbon bond formation via sulfonyl iminium ions generated from N,S-sulfonyl acetals
Silveira, Claudio C.,Bernardi, Carmem R.,Braga, Antonio L.,Kaufman, Teodoro S.
, p. 6137 - 6140 (2003)
The elaboration of 1-alkylthio- and 1-arylthio-tetrahydroisoquinolines by means of the activated Pictet-Spengler reaction of N-sulfonyl-β-phenethylamines with thioorthoesters as electrophiles, and their use as sulfonyl iminium ion precursors for carbon-carbon bond formation, leading to 1-substituted tetrahydroisoquinoline derivatives, is reported.
