471929-86-9

Basic information

• Product Name: 4-(PIPERIDIN-1-YLMETHYL)BENZALDEHYDE
• Synonyms: 1-(4-CARBOXALDEHYDEBENZYL)PIPERIDINE;4-(PIPERIDIN-1-YLMETHYL)BENZALDEHYDE;4-(Piperidin-1-ylmethyl)benzaldehyde 95%;4-(1-piperidylmethyl)benzaldehyde;4-(piperidinomethyl)benzaldehyde;4-(Piperidin-1-ylmethyl)benzaldehyde95%
• CAS NO: 471929-86-9
• Molecular Formula: C₁₃H₁₇NO
• Molecular Weight: 203.28
• Mol File: 471929-86-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 316.7 °C at 760 mmHg
• Flash Point: 114.9 °C
• Appearance: /
• Density: 1.084 g/cm³
• Vapor Pressure: 0.000403mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 4-(PIPERIDIN-1-YLMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(PIPERIDIN-1-YLMETHYL)BENZALDEHYDE(471929-86-9)
• EPA Substance Registry System: 4-(PIPERIDIN-1-YLMETHYL)BENZALDEHYDE(471929-86-9)

Safety Data

• Hazard Codes: C
• HazardClass: IRRITANT
• Hazardous Substances Data: 471929-86-9(Hazardous Substances Data)

Usage

General Description

4-(piperidin-1-ylmethyl)benzaldehyde is a chemical compound with the molecular formula C14H17NO. It is a benzaldehyde derivative with a piperidinylmethyl group attached to the benzene ring. 4-(PIPERIDIN-1-YLMETHYL)BENZALDEHYDE is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and fine chemicals. It has also been studied for its potential biological activities, including its role as a ligand in drug-receptor interactions. The compound's structure and reactivity make it a versatile intermediate for the synthesis of complex molecules and may have potential applications in medicinal chemistry.

InChI:InChI=1/C13H17NO/c15-11-13-6-4-12(5-7-13)10-14-8-2-1-3-9-14/h4-7,11H,1-3,8-10H2

Upstream product

• 110-89-4 piperidine 
• 81172-89-6 terephthalaldehyde mono(diethylacetal) 
• 104-88-1 4-chlorobenzaldehyde 
• 105-07-7 4-cyanobenzaldehyde 
• 52010-97-6 4-(hydroxylmethyl)benzaldehyde 
• 623-27-8 terephthalaldehyde, 
• 51359-78-5 4-(bromomethyl)benzaldehyde 
• 91271-62-4 (4-(piperidin-1-ylmethyl)phenyl)methanol 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 1268340-93-7 N-(trifluoroboratomethyl)piperidine internal salt 
• 69088-97-7 methanesulfonic acid 4-formylphenyl ester 

Downstream Products

• 1366232-92-9 C₂₇H₃₀N₄O 
• 1350648-19-9 2,3-diamino-N₂-(4-(piperidin-1-ylmethyl)benzylidene)quinoxaline 
• 1192281-26-7 (E)-1-(2-hydroxy-4,5-dimethoxyphenyl)-3-[4-(piperidin-1-ylmethyl)-phenyl]-prop-2-en-1-one 

Relevant articles and documents

Structural variations of 1-(4-(phenoxymethyl)benzyl)piperidines as nonimidazole histamine H3 receptor antagonists

Recent bioisoteric replacements in histamine H3 receptor ligands with an exchange of the imidazole moiety by a piperidino group as well as of the trimethylene chain in 4-((3-phenoxy)propyl)-lH-imidazole derivatives (proxifan class) by an α,α′-xylendiyl linker represents the starting point in the development of 1-(4-(phenoxymethyl)benzyl) piperidines as a new class of nonimidazole histamine H3 receptor antagonists. According to different strategies in optimization of imidazole-containing antagonists the central benzyl phenyl ether moiety was replaced by numerous other polar functionalities. Additionally, the ortho- and meta-analogues of the lead were synthesized to determine the influence of the position of the piperidinomethyl substituent. The new compounds were tested in an in vitro binding assay for their affinities for cloned human H3 receptors stably expressed in CHO-K1 cells and for their oral in vivo potencies brain in a functional screening assay in the brain of mice. Additionally, activities of selected compounds were determined in the guinea-pig ileum functional test model. In contrast to the analogues ortho-substituted compounds all other compounds maintained respectable affinities for the human H 3 receptor (-logKi values 6.3-7.5). Despite the results from other classes of compounds the 4-methyl substituted derivatives generally displayed higher affinities than the corresponding 4-chloro substituted compounds. In vivo only the inverse phenyl benzyl ether (3) showed worthwhile antagonist potencies.

IMIDAZO [2, 1-F] [1, 2, 4] TRIAZIN-4-AMINE DERIVATIVES AS TLR7 AGONIST

Disclosed herein is an imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof useful as a TLR7 agonist, and a pharmaceutical composition comprising the same. Also disclosed herein is a method of treating cancer using the imidazo [2, 1-f] [1, 2, 4] triazin-4-amine derivative or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof as TLR7 agonist.

Hydroxamic acid derivative, and preparation method and application thereof

The invention relates to the technical field of enzyme inhibitors, and especially relates to a hydroxamic acid derivative, and a preparation method and an application thereof. A hydroxamic acid groupin the hydroxamic acid derivative is chelated with activ