471933-66-1Relevant articles and documents
Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current I Ks
Ahmad, Saleem,Doweyko, Lidia,Ashfaq, Aaila,Ferrara, Francis N.,Bisaha, Sharon N.,Schmidt, Joan B.,DiMarco, John,Conder, Mary Lee,Jenkins-West, Tonya,Normandin, Diane E.,Russell, Anita D.,Smith, Mark A.,Levesque, Paul C.,Lodge, Nicholas J.,Lloyd, John,Stein, Philip D.,Atwal, Karnail S.
, p. 99 - 102 (2007/10/03)
Class III anti-arrhythmic drugs (e.g., dofetilide) prolong cardiac action potential duration (APD) by blocking the fast component of the delayed rectifier potassium current (IKr). The block of IKr can result in life threatening ventr