4720-86-9

Basic information

• Product Name: 3,4,5,6-Tetrahydrophthalimide
• Synonyms: 1-Cyclohexene-1,2-dicarboximide;3,4,5,6-TETRAHYDROPHTHALIMIDE;DELTA1-Tetrahydrophthalimide;3,4,5,6-TETRAHYDROPHTHALIMIDE 96.0% [4720-86-9] C8H9NO2 FW151.16;4,5,6,7-Tetrahydro-1H-izoindol-1,3(2H)-dione;3,4,5,6-Tetrahydro ;3，4，5，6-tetrahydro-o-phthalimide;4,5,6,7-Tetrahydro-1H-isoindole-1,3(2H)-dione
• CAS NO: 4720-86-9
• Molecular Formula: C₈H₉NO₂
• Molecular Weight: 151.16
• EINECS: 225-211-7
• Product Categories: Diels-Alder Adducts
• Mol File: 4720-86-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 170-175 °C (sublm)(Solv: benzene (71-43-2))
• Boiling Point: 324.3 °C at 760 mmHg
• Flash Point: 158.1 °C
• Appearance: slight yellow to white crystalline powder
• Density: 1.27 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 9.49±0.20(Predicted)
• CAS DataBase Reference: 3,4,5,6-Tetrahydrophthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5,6-Tetrahydrophthalimide(4720-86-9)
• EPA Substance Registry System: 3,4,5,6-Tetrahydrophthalimide(4720-86-9)

Safety Data

• Hazardous Substances Data: 4720-86-9(Hazardous Substances Data)

Usage

Chemical Properties

slight yellow to white crystalline powder

Upstream product

• 136918-14-4 phthalimide 
• 2426-02-0 3,4,5,6-Tetrahydrophthalic anhydride 
• 57-13-6 urea 

Downstream Products

• 7506-66-3 cis-hexahydrophthalimide 
• 635-08-5 cyclohex-1-ene-1,2-dicarboxylic acid 
• 4887-42-7 N-hydroxymethyl-3,4,5,6-tetrahydrophthalimide 

Relevant articles and documents

Design, Synthesis, and Herbicidal Activity of Novel Diphenyl Ether Derivatives Containing Fast Degrading Tetrahydrophthalimide

To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle of substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is the most potential compound, with the half-maximal inhibitory concentration (IC50) value of 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize PPO and similar herbicidal activities to Oxyfluorfen in weeding experiments in greenhouses and field weeding experiments. In view of the inspected bioactivities, the structure-activity relationship (SAR) of this series of compounds was also discussed. Crop selection experiments demonstrate that compound 6c is safe for soybeans, maize, rice, peanuts, and cotton at a dose of 300 g ai/ha. Accumulation analysis experiments showed that the accumulation of 6c in some crops (soybeans, peanuts, and cotton) was significantly lower than Oxyfluorfen. Current work suggests that compound 6c may be developed as a new herbicide candidate in fields.

AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES

The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C1 represents H or -CH3, R6 and R7 both represent H, n is an integer from 0 to 4 inclusive, G represents a cyclic amide or imide moiety, and optical isomers, geometric isomers, and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.