47209-42-7Relevant academic research and scientific papers
Design, syntheses and antitumor activities evaluation of 1,5-diaryl substituted pyrazole secnidazole ester derivatives
Teng, Qing-Hu,Sun, Gui-Xia,Luo, Shu-Ying,Wang, Kai,Liang, Fu-Pei
supporting information, p. 1656 - 1664 (2021/05/29)
According to the drug hybridization principle, a series of novel 1,5-diaryl substituted pyrazole secnidazole ester derivatives (6aa–6gc) have been synthesized by the combinations of various 1,5-diarylpyrazole-3-carboxylic acids with secnidazole. The in vi
Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation
Chen, Long-Wang,Wang, Peng-Fei,Tang, Dan-Jie,Tao, Xiang-Xiang,Man, Ruo-Jun,Qiu, Han-Yue,Wang, Zhong-Chang,Xu, Chen,Zhu, Hai-Liang
, p. 592 - 598 (2016/10/19)
As an important enzyme in bacterial protein biosynthesis, tyrosyl-tRNA synthetase (TyrRS) has been an absorbing therapeutic target for exploring novel antibacterial agents. A series of metronidazole-based antibacterial agents has been synthesized and iden
