4722-76-3 Usage
Uses
Used in Pharmaceutical Industry:
5-bromo-2-methyl-1H-pyrimidine-4,6-dione is used as a synthetic intermediate for the development of pharmaceuticals. Its unique structure allows it to be a key component in the creation of new drugs, contributing to advancements in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-bromo-2-methyl-1H-pyrimidine-4,6-dione is utilized as a building block in the synthesis of agrochemicals. Its properties make it suitable for the development of compounds that can be used in crop protection and other agricultural applications.
Used as a Precursor in Organic Chemistry:
5-bromo-2-methyl-1H-pyrimidine-4,6-dione is employed as a precursor in the production of various organic compounds, including pyrimidine derivatives. Its versatility in organic synthesis makes it valuable for the creation of a wide range of chemical products.
Safety Considerations:
When handling 5-bromo-2-methyl-1H-pyrimidine-4,6-dione, it is important to be aware of its potential to cause irritation to the skin, eyes, and respiratory system. To mitigate these risks, proper safety measures should be taken, including the use of personal protective equipment and ensuring the work area is well-ventilated.
Check Digit Verification of cas no
The CAS Registry Mumber 4722-76-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,2 and 2 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 4722-76:
(6*4)+(5*7)+(4*2)+(3*2)+(2*7)+(1*6)=93
93 % 10 = 3
So 4722-76-3 is a valid CAS Registry Number.
4722-76-3Relevant academic research and scientific papers
Conformational analysis of tandospirone in aqueous solution: Lead evolution of potent dopamine D4 receptor ligands
Nishimura, Tamiki,Igarashi, Jun-etsu,Sunagawa, Makoto
, p. 1141 - 1144 (2007/10/03)
The significant contribution of folded conformation (2) of the anxiolytic tandospirone (1) in aqueous solution was verified by dynamic 1H NMR. A structurally rigid mimic of 2 was designed and synthesized to evaluate the implication of 2 towards neuroleptic receptor binding. The designed structures provided a new rigid scaffold for dopamine D4 ligands.
Ylides of Heterocycles. VII. . I-, N-, P- and S-Ylides of Pyrimidones
Habib, Nargues Samuel,Kappe, Thomas
, p. 385 - 388 (2007/10/02)
The reaction of pyrimidone derivatives 1a-d with iodosobenzene prepared in situ from diacetoxyiodobenzene or dichloroiodobenzene afforded the iodonium-ylides 2a-d in good yields.Their thermal rearrangement produced 5-iodo-4-phenoxy-pyrimidin-6(1H)-ones 3a-c.Reductive deiodination of 3 gave the corresponding 4-phenoxypyrimidin-6(1H)-ones 4a-c.Acid catalized treatment of the iodonium-ylides 2a-d with nucleophiles such as pyridine, nicotinamide, isoquinoline, or triphenylphosphine produced the corresponding N- or P-ylides 7, 8, 9, and 10, respectively.The thiophanium-ylides 11a,c were obtained from the iodonium-ylides 2 without the use of a catalyst.The pyridinium-ylides 7 have also been prepared from the 5-halopyrimidones 5 or 6 which in turn could be obtained from the reactive iodonium-ylides 2 with hydrochloric or hydrobromic acid, respectively.
