4725-51-3

Basic information

• Product Name: Androstane-3,5,6-triol,(3,5,6)-(9CI)
• Synonyms: Androstane-3,5,6-triol,(3,5,6)-(9CI);YC-6;(3S,5R,6R,8S,9S,10R,13S,14S)-10,13-DiMethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,5,6-triol;YC-6C;5alpha-Androstane-3beta,5,6beta-triol;(3beta,5alpha,6beta)-Androstane-3,5,6-triol
• CAS NO: 4725-51-3
• Molecular Formula: C₁₉H₃₂O₃
• Molecular Weight: 308.45558
• Mol File: 4725-51-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 208-213 °C(Solv: acetone (67-64-1); ligroine (8032-32-4))
• Boiling Point: 430.1±35.0 °C(Predicted)
• Appearance: /
• Density: 1.187±0.06 g/cm3(Predicted)
• PKA: 14.27±0.70(Predicted)
• CAS DataBase Reference: Androstane-3,5,6-triol,(3,5,6)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Androstane-3,5,6-triol,(3,5,6)-(9CI)(4725-51-3)
• EPA Substance Registry System: Androstane-3,5,6-triol,(3,5,6)-(9CI)(4725-51-3)

Safety Data

• Hazardous Substances Data: 4725-51-3(Hazardous Substances Data)

Usage

General Description

Androstane-3,5,6-triol, (3,5,6)-(9CI) is a chemical compound derived from androstane, a steroid compound. This particular variant includes three hydroxyl (OH) groups attached to the androstane backbone at positions 3, 5, and 6, making it a triol. It is a member of the androstanes, a group of steroids with 19 carbon atoms that form the basis of many bioactive steroids in mammals. Like other androstane derivatives, it may have biological or pharmaceutical applications, but the specific properties and uses of Androstane-3,5,6-triol, (3,5,6)-(9CI) are not specifically documented. Its properties, like those of other steroids, would be influenced by the location and properties of its functional groups.

Upstream product

• 4725-50-2 5α,6α-epoxyandrostan-3β-ol 
• 5223-91-6 3β-Acetoxy-5α,6α-epoxyandrostan 
• 25706-90-5 3-hydroxy-5-androstene 
• 53-43-0 dehydroepiandrosterone 
• 1450917-20-0 3β,6β-diformyloxy-5α-androst-5-ol 
• 4725-55-7 Acetic acid (3S,5R,6R,8S,9S,10R,13S,14S)-5,6-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 1476-64-8 androst-5-en-3β-ol 

Relevant articles and documents

Sulfuric acid hydrolysis of 3-beta-hydroxy-5-alpha, 6-alpha-epoxyandrostane.

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2?,3a,5a-TRIHYDROXY-ANDROST-6-ONE AND PREPARATION METHODS AND USE THEREOF

The present invention discloses compound 2β,3α,5α-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound.

A synthetic steroid 5α-Androst-3β,5,6-Triol blocks hypoxia/reoxygenation - Induced neuronal injuries via protection of mitochondrial function

Ischemic stroke is a leading cause of death worldwide, yet therapies are limited. During periods of ischemia following reperfusion in ischemic stroke, not only loss of energy supply, but a few other factors including mitochondrial dysfunction and oxidative stress also make vital contribution to neuronal injury. Here we synthesized a steroid compound 5α-androst-3β,5, 6β-triol by 3 steps starting from dehydroepiandrosterone and examined its effect on mitochondrial function and oxidative stress in primary cultured cortical neurons exposed to hypoxia followed by reoxygenation. 5α-Androst-3β,5,6β-triol dose-dependently protected cortical neurons from hypoxia/reoxygenation exposure. Rates of reduction in neuronal viability, loss of mitochondrial membrane potential, disruption of ATP production and oxidative stress were ameliorated in 5α-androst-3β,5, 6β-triol pretreated cultures. In summary, these results suggest that 5α-androst-3β,5,6β-triol is neuroprotective against hypoxia/reoxygenation induced neuronal injuries through mediation of mitochondrial function and oxidative stress.