4725-51-3

Usage

Uses

Used in Pharmaceutical Industry:
Androstane-3,5,6-triol, (3,5,6)-(9CI) is used as a potential bioactive compound for its potential role in the development of new pharmaceuticals. The presence of three hydroxyl groups at positions 3, 5, and 6 may allow for the formation of various derivatives with different biological activities, making it a candidate for further research and development in drug discovery.
Used in Research Applications:
Androstane-3,5,6-triol, (3,5,6)-(9CI) is used as a research chemical for studying the structure-activity relationships of androstane derivatives. The unique arrangement of hydroxyl groups in Androstane-3,5,6-triol,(3,5,6)-(9CI) may provide insights into the effects of functional group placement on the biological activity of steroids, which could be valuable for the design of new therapeutic agents.
Used in Chemical Synthesis:
Androstane-3,5,6-triol, (3,5,6)-(9CI) is used as a starting material or intermediate in the synthesis of other steroidal compounds. The presence of three hydroxyl groups at specific positions on the androstane backbone may facilitate the formation of a variety of steroidal derivatives, making it a useful building block in the synthesis of complex steroidal molecules.

Upstream product

• 4725-50-2 5α,6α-epoxyandrostan-3β-ol 
• 1450917-20-0 3β,6β-diformyloxy-5α-androst-5-ol 
• 53-43-0 dehydroepiandrosterone 
• 25706-90-5 3-hydroxy-5-androstene 
• 5223-91-6 3β-Acetoxy-5α,6α-epoxyandrostan 
• 4725-55-7 Acetic acid (3S,5R,6R,8S,9S,10R,13S,14S)-5,6-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 1476-64-8 androst-5-en-3β-ol 

Relevant academic research and scientific papers

2?,3a,5a-TRIHYDROXY-ANDROST-6-ONE AND PREPARATION METHODS AND USE THEREOF

The present invention discloses compound 2β,3α,5α-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound.

Design and synthesis of polyhydroxy steroids as selective inhibitors against AKR1B10 and molecular docking

AKR1B10 is a member of the human aldo-keto reductase superfamily which is highly expressed in several types of cancers, and has been regarded as a promising cancer therapeutic target. In this paper, a series of polyhydroxy steroids were designed and synthesized to selectively inhibit AKR1B10 activity. The most selective compound, novel compound 6, has an IC50 of 0.83 ± 0.07 μM and a selectivity of more than 120-fold for AKR1B10/AKR1B1. Structure-activity relation analyses indicate that hydroxyl at C-19 can significantly improve the selective inhibition of AKR1B10. The binding mode of AKR1B10 and its inhibitors were studied.

2β,3α,5α-TRIHYDROXY-ANDROST-6-ONE AND PREPARATION METHODS AND USES THEREOF

The present invention discloses compound 22,3±,5±-trihydroxy-androst-6-one, having the structure of formula (I). The present invention also discloses a plurality of methods for preparing the compound and a use of the compound.

A synthetic steroid 5α-Androst-3β,5,6-Triol blocks hypoxia/reoxygenation - Induced neuronal injuries via protection of mitochondrial function

Ischemic stroke is a leading cause of death worldwide, yet therapies are limited. During periods of ischemia following reperfusion in ischemic stroke, not only loss of energy supply, but a few other factors including mitochondrial dysfunction and oxidative stress also make vital contribution to neuronal injury. Here we synthesized a steroid compound 5α-androst-3β,5, 6β-triol by 3 steps starting from dehydroepiandrosterone and examined its effect on mitochondrial function and oxidative stress in primary cultured cortical neurons exposed to hypoxia followed by reoxygenation. 5α-Androst-3β,5,6β-triol dose-dependently protected cortical neurons from hypoxia/reoxygenation exposure. Rates of reduction in neuronal viability, loss of mitochondrial membrane potential, disruption of ATP production and oxidative stress were ameliorated in 5α-androst-3β,5, 6β-triol pretreated cultures. In summary, these results suggest that 5α-androst-3β,5,6β-triol is neuroprotective against hypoxia/reoxygenation induced neuronal injuries through mediation of mitochondrial function and oxidative stress.