4725-53-5

Upstream product

• 1476-64-8 androst-5-en-3β-ol 
• 53-43-0 dehydroepiandrosterone 
• 13067-44-2 3β-acetoxyandrost-5-ene 
• 67145-22-6 Acetic acid (3S,8S,9S,10R,13S,14S)-10,13-dimethyl-hexadecahydro-20-oxa-cyclopropa[5,6]cyclopenta[a]phenanthren-3-yl ester 
• 4725-55-7 Acetic acid (3S,5R,6R,8S,9S,10R,13S,14S)-5,6-dihydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 

Relevant academic research and scientific papers

One-pot, high yield synthesis of α-ketols from Δ5- steroids

α-Hydroxy ketones (α-ketols) are present in many compounds with biological activity. Several methods are available for the preparation of α-ketols but only a few of them describe the synthesis of steroid α-ketols from olefins. In this work, a new system c

Synthesis of cytotoxic 6E-hydroximino-4-ene steroids: Structure/activity studies

In an effort to determine the pharmaceutical utility and the structural requirements for activity against various tumor cell lines, several 6E-hydroximino-4-ene steroids with different side chains and degrees of unsaturation on ring A were synthesized in our laboratory. Evaluation of the synthesized compounds for cytotoxicity against P-388, A-549, HT-29, and MEL-28 tumor cells revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biological activity, the existence of a ketone functionality at C-3, and an elevated degree of oxidation on ring A all result in higher bioctivity than other structural motifs.