4727-40-6 Usage
General Description
S-methylmethionine, also known as vitamin U, is a naturally occurring compound found in a variety of plant foods, including cabbage, Brussels sprouts, and other cruciferous vegetables. It is a derivative of the amino acid methionine and is recognized for its potential health benefits, including promoting liver health and reducing inflammation. Some studies have also suggested that S-methylmethionine may have anticancer properties and could help protect against gastric ulcers. Additionally, it is thought to support the production of the antioxidant glutathione, which helps the body combat oxidative stress. Overall, S-methylmethionine is an intriguing chemical compound with potential implications for human health, though more research is needed to fully understand its mechanisms and potential therapeutic uses.
Check Digit Verification of cas no
The CAS Registry Mumber 4727-40-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,2 and 7 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 4727-40:
(6*4)+(5*7)+(4*2)+(3*7)+(2*4)+(1*0)=96
96 % 10 = 6
So 4727-40-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO2S/c1-10(2)4-3-5(7)6(8)9/h5H,3-4,7H2,1-2H3/t5-/m0/s1
4727-40-6Relevant articles and documents
Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor
Franke, Jakob,Hertweck, Christian,Ishida, Keishi,Ishida-Ito, Mie,Kries, Hajo,Pohnert, Georg,Stani?i?, Aleksa,Trottmann, Felix
, p. 13511 - 13515 (2020)
Pathogenic bacteria of the Burkholderia pseudomallei group cause severe infectious diseases such as glanders and melioidosis. Malleicyprols were identified as important bacterial virulence factors, yet the biosynthetic origin of their cyclopropanol warhead has remained enigmatic. By a combination of mutational analysis and metabolomics we found that sulfonium acids, dimethylsulfoniumpropionate (DMSP) and gonyol, known as osmolytes and as crucial components in the global organosulfur cycle, are key intermediates en route to the cyclopropanol unit. Functional genetics and in vitro analyses uncover a specialized pathway to DMSP involving a rare prokaryotic SET-domain methyltransferase for a cryptic methylation, and show that DMSP is loaded onto the NRPS-PKS hybrid assembly line by an adenylation domain dedicated to zwitterionic starter units. Then, the megasynthase transforms DMSP into gonyol, as demonstrated by heterologous pathway reconstitution in E. coli.
