472965-86-9Relevant academic research and scientific papers
Synthesis and self-assembly of DNA-chromophore hybrid amphiphiles
Albert, Shine K.,Golla, Murali,Thelu, Hari Veera Prasad,Krishnan, Nithiyanandan,Deepak, Perapaka,Varghese, Reji
, p. 6960 - 6969 (2016/07/30)
DNA based spherical nanostructures are one of the promising nanostructures for several biomedical and biotechnological applications due to their excellent biocompatibility and DNA-directed surface addressability. Herein, we report the synthesis and amphiphilicity-driven self-assembly of two classes of DNA (hydrophilic)-chromophore (hydrophobic) hybrid amphiphiles into spherical nanostructures. A solid-phase "click" chemistry based modular approach is demonstrated for the synthesis of DNA-chromophore amphiphiles. Various spectroscopic and microscopic analyses reveal the self-assembly of the amphiphiles into vesicular and micellar assemblies with the corona made of hydrophilic DNA and the hydrophobic chromophoric unit as the core of the spherical nanostructures.
Supramolecular micelle from amphiphilic Mn(III)-porphyrin derivatives as a potential MRI contrast agent
Choi, Kwangmo,Lee, Do-Hyung,Jang, Woo-Dong
experimental part, p. 639 - 644 (2010/08/20)
Amphiphilic porphyrin derivatives have been synthesized and characterized by 1H NMR and MALDI-TOF-MS. All porphyrin derivatives showed very high solubility to aqueous medium as well as hydrophobic organic solvent. The UVvis absorption of the porphyrin derivatives showed significant broadness and decrease of maximum intensity of absorption in aqueous solution. SEM experiment showed the formation of spherical micellar structure. The T1 relaxation time of aqueous medium was drastically decreased in the presence of Mn(III)-porphyrin derivative, indicating that the supramolecular micelle has strong possibility to use as a T1 contrast agent.
