473-42-7

Basic information

• Product Name: Nitrosulfathiazole
• Synonyms: Nitrosulfathiazole;4-nitro-N-(1,3-thiazol-2-yl)benzenesulfonamide;4-Nitro-N-(2-thiazolyl)benzenesulfonamide;Nisulfazole;p-Nitrosulfathiazole;p-Nitrosulphathiazole;4-nitro-N-thiazol-2-yl-benzenesulfonamide
• CAS NO: 473-42-7
• Molecular Formula: C₉H₇N₃O₄S₂
• Molecular Weight: 285.3
• Mol File: 473-42-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 495°Cat760mmHg
• Flash Point: 253.2°C
• Appearance: /
• Density: 1.648g/cm³
• Vapor Pressure: 6.11E-10mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: Nitrosulfathiazole(CAS DataBase Reference)
• NIST Chemistry Reference: Nitrosulfathiazole(473-42-7)
• EPA Substance Registry System: Nitrosulfathiazole(473-42-7)

Safety Data

• Hazardous Substances Data: 473-42-7(Hazardous Substances Data)

Usage

Chemical Properties

Pale-yellow powder; odorless; slightly bitter taste.Slightly soluble in alcohol; very slightly soluble in chloroform, ether and water; practically insoluble in benzene.

Brand name

Nisulfazole (Sterling Winthrop).

InChI:InChI=1/C9H7N3O4S2/c13-12(14)7-1-3-8(4-2-7)18(15,16)11-9-10-5-6-17-9/h1-6H,(H,10,11)

Upstream product

• 96-50-4 2-thiazolylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 13088-17-0 4-nitro-benzenesulfinyl chloride 

Downstream Products

• 935266-70-9 N-{1-methyl-3-[2-(4-phenoxy-phenoxy)-thiazol-5-yl]-prop-2-ynyl}-4-nitro-N-thiazol-2-yl-benzenesulfonamide 
• 858500-74-0 4-nitro-benzenesulfonic acid-(methyl-thiazol-2-yl-amide) 
• 14945-47-2 4-nitro-N-(3-xanthen-9-yl-3H-thiazol-2-ylidene)-benzenesulfonamide 
• 72-14-0 Sulfathiazole 

Relevant articles and documents

3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidinand N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N 1propylglycinamide

A series of compounds containing the nitrobenzene and sulfonamido moieties were synthesized and their leishmanicidal effect was assessed in vitro against Leishmania infantum promastigotes. Among the compounds evaluated, the p-nitrobenzenesulfonamides 4Aa

The synthesis and structure-activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications

The structure-activity relationship study focused on the polar region of the HTS hit A-80040 (1) producing several series of potent and selective ACC2 inhibitors. The SAR suggests a compact lipophilic pocket that does not tolerate polar and ionic groups.