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4730-77-2

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4730-77-2 Usage

General Description

1-NAPHTHYLMETHYLPHOSPHONIC ACID, also known as Naptalam, is a phosphonic acid-based chemical that is commonly used as a herbicide to control a wide range of broadleaf and grassy weeds in various crops. It works by inhibiting the enzyme acetolactate synthase, which is essential for the biosynthesis of branched-chain amino acids in plants. This leads to the disruption of normal plant growth and eventually leads to the death of the targeted weeds. The compound is effective against many weed species and is often used in combination with other herbicides to enhance its efficacy. However, it is important to handle and apply 1-NAPHTHYLMETHYLPHOSPHONIC ACID with caution due to its potential toxicity to humans and the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 4730-77-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,3 and 0 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4730-77:
(6*4)+(5*7)+(4*3)+(3*0)+(2*7)+(1*7)=92
92 % 10 = 2
So 4730-77-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H11O3P/c12-15(13,14)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7H,8H2,(H2,12,13,14)

4730-77-2Downstream Products

4730-77-2Relevant articles and documents

Inhibition of purple acid phosphatase with α-alkoxynaphthylmethylphosphonic acids

McGeary, Ross P.,Vella, Peter,Mak, Jeffrey Y.W.,Guddat, Luke W.,Schenk, Gerhard

supporting information; experimental part, p. 163 - 166 (2009/04/10)

Purple acid phosphatases (PAPs) are binuclear hydrolases that catalyse the hydrolysis of a range of phosphorylated substrates. Human PAP is a major histochemical marker for the diagnosis of osteoporosis. In patients suffering from this disorder, PAP activity contributes to increased bone resorption and, therefore, human PAP is a key target for the development of anti-osteoporotic drugs. This manuscript describes the design and synthesis of derivatives of 1-naphthylmethylphosphonic acids as inhibitors of PAP. The Ki values of these compounds are as low as 4 μM, the lowest reported to date for a PAP inhibitor.

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