473000-07-6Relevant academic research and scientific papers
Synthesis and antiplatelet effects of ω-aminoalkoxylxanthones
Lin,Liou,Lai,Lin,Ko,Liu,Teng
, p. 588 - 594 (1995)
A series of ω-aminoalkoxylxanthones were synthesized and tested in-vitro for their ability to inhibit aggregation of rabbit washed platelets and human platelet-rich plasma (PRP) induced by various inducers. Nine of these compounds showed more potent antiplatelet effects than natural norathyriol tetraacetate on collagen-induced aggregation. The various ω-aminoalkoxyl side chains of the synthesized compounds modified the antiplatelet effects. All the compounds tested in human PRP showed significant inhibition of secondary aggregation induced by adrenaline, suggesting that the antiplatelet effects of these compounds is mainly due to an inhibitory effect on thromboxane formation. These compounds at high concentration also cause vasorelaxing action in rat thoracic aorta.
Synthesis and cytotoxic evaluation of potential bis-intercalators: Tetramethylenebis(oxy)- and hexamethylenebis(oxy)-linked assemblies consisting of flavone, xanthone, anthraquinone, and dibenzofuran
Wang, Tai-Chi,Zhao, Yue-Ling,Liou, Shorong-Shii
, p. 1382 - 1389 (2002)
In a search for potential inhibitors of solid-tumor growth, certain alkanediylbis(oxy)-linked assemblies were synthesized and evaluated for their cytotoxicity as bis-intercalators. Symmetrical assemblies 1b-12b were synthesized from their respective Aryl-OH and either dibromobutane or dibromohexane, while unsymmetrical ones 13-15 were prepared from Aryl1OH and either Aryl2-O-(CH2)4Br or Aryl2-O-(CH2)6Br. These bisintercalators were inactive against the growth of leukemia cells. However, some of them were active against the growth of certain solid tumors such as HOP-62, HOP-92 (non-small-cell lung cancer), SF-265, SNB-75, U251 (CNS cancer), A498 (renal cancer), and HS578T (breast cancer). Among them, [hexane-1,6-diylbis(oxy)-bis(4,1-phenylene)]bis[4H-1-benzopyran] (6b) was especially active against the growth of all CNS cancer cell lines and also the growth of A498, HOP-62, and HOP-92 with Gl50 values of 17.0, 20.0, and 21.8 μm, respectively.
Synthesis, antiplatelet and vasorelaxing activities of xanthone derivatives
Lin, Kai-Wei,Fang, Song-Chwan,Hung, Chi-Feng,Shieh, Bor-Jinn,Yang, Shyh-Chyun,Teng, Che-Ming,Lin, Chun-Nan
experimental part, p. 19 - 26 (2009/05/27)
A series of ω-aminoalkoxylxanthones was synthesized and tested in vitro for their ability to inhibit platelet aggregation and cause vasorelaxing action. Compounds 4, 5, 12, 17, and 18 showed significant antiplatelet effects on thrombin-, arachidonic acid (AA)-, collagen-, and platelet activating factor (PAF)-induced washed rabbit platelet aggregation and exhibited inhibition of primary and secondary aggregation induced by adenosine-5′-diphosphate (ADP) in human platelet-rich-plasma (PRP). Compounds 4, 17, and 18 revealed vasorelaxing activities in rat thoracic aorta. We concluded that these compounds may be developed as new antithrombotic agents.
