473230-79-4Relevant academic research and scientific papers
Angiogenesis inhibitor epoxyquinol a: total synthesis and inhibition of transcription factor NF-kappaB.
Li, Chaomin,Bardhan, Sujata,Pace, Emily A,Liang, Mei-Chih,Gilmore, Thomas D,Porco Jr., John A
, p. 3267 - 3270 (2002)
[reaction: see text] The asymmetric synthesis of the natural product (+)-epoxyquinol A (1) and related epoxyquinoid dimers, employing a cascade oxidation/electrocyclization/Diels-Alder dimerization sequence, is reported. In addition, we show that 1 and related molecules inhibit activation of the transcription factor NF-kappaB.
Synthesis of epoxyquinol A and related molecules: Probing chemical reactivity of epoxyquinol dimers and 2H-pyran precursors
Li, Chaomin,Porco Jr., John A.
, p. 6053 - 6065 (2007/10/03)
Total syntheses of the epoxyquinoid dimers, epoxyquinols A, B, and epoxytwinol A (RKB-3564 D), have been accomplished employing [4 + 2] and [4 + 4] dimerization of 2H-pyran epoxyquinol monomers. Modifications of 2H-pyran precursors have been explored, inc
