4734-98-9

Usage

Uses

Used in Chemical Synthesis Industry:
Benzo[cd]indole-2(1H)-thione is used as a reactant for the synthetic preparation of fluorescent dyes. Its distinctive molecular structure allows for the creation of dyes with specific optical properties, which are essential for various applications such as bioimaging, sensing, and other analytical techniques.
In the field of chemical synthesis, benzo[cd]indole-2(1H)-thione serves as a key intermediate in the preparation of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its reactivity and structural features make it a valuable component in the development of new molecules with desired properties.
Furthermore, benzo[cd]indole-2(1H)-thione may also find applications in materials science, where its unique electronic and optical properties could be harnessed for the development of novel materials with potential uses in optoelectronics, photovoltaics, and other advanced technologies.
Overall, benzo[cd]indole-2(1H)-thione is a versatile and promising compound with a broad range of potential applications across various industries, including chemical synthesis, pharmaceuticals, materials science, and analytical chemistry. Its unique structure and properties make it an attractive candidate for further research and development to unlock its full potential in these fields.

Upstream product

• 130-00-7 1,8-naphtholactam 
• 551-06-4 1-isothiocyanatonaphthalene 

Downstream Products

• 112717-74-5 4-(1H-benz[cd]indol-2-ylidene)-5-methyl-2-p-tolyl-2,4-dihydro-pyrazol-3-one 
• 1012-94-8 2-Oximino-1,2-dihydro-benzindol 
• 39273-39-7 1-butylbenzo[c,d]indol-2(1H)-one 

Relevant academic research and scientific papers

Thioanhydrides. 3. Synthesis, Properties, and Diels-Alder Reactions of Sulfur Analogues of 1,8-Naphthalic Anhydride

All five possible sulfur analogues of 1,8-naphthalic anhydride have been synthesized by practical procedures, starting from 1,8-naphthalic anhydride.The thionoanhydrides containing an oxygen bridge rearrange readily to thiolo isomers under tertiary amine catalysis, and all of the thionoanhydrides undergo (4 + 2) cycloadditions with norbornylene.In addition, other α-thiono-substituted naphthalenes have been probed in the norbornylene addition reaction, and some observations have been made concerning the mechanism of the Pedersen thionation reaction.

NOVEL COMPOUND

PROBLEM TO BE SOLVED: To provide a novel compound having excellent base generation performance. SOLUTION: There is provided a novel compound represented by the following general formula (1'), wherein a ring A1 is one of following partial structural formulae (1-1) to (1-10), R1 and R2 are each independently a hydrogen atom, an unsubstituted or substituted hydrocarbon group with 1 to 20 carbon atoms, or R1 and R2 are connected each other to form a ring containing a nitrogen atom, when an atom constituting a 5- to 8-membered ring represented by the ring A1 contains no nitrogen atom, R1 and R2 are the ring formed by connecting each other, the ring is formed optionally selected from a nitrogen atom, an oxygen atom, and a carbon atom, and a benzene ring may be condensed to the ring. SELECTED DRAWING: None COPYRIGHT: (C)2019,JPOandINPIT

Second Generation G-Quadruplex Stabilizing Trimethine Cyanines

G-Quadruplex DNA has been recognized as a highly appealing target for the development of new selective chemotherapeutics, which could result in markedly reduced toxicity toward normal cells. In particular, the cyanine dyes that bind selectively to G-quadruplex structures without targeting duplex DNA have attracted attention due to their high amenability to structural modifications that allows fine-tuning of their biomolecular interactions. We have previously reported pentamethine and symmetric trimethine cyanines designed to effectively bind G-quadruplexes through end stacking interactions. Herein, we are reporting a second generation of drug candidates, the asymmetric trimethine cyanines. These have been synthesized and evaluated for their quadruplex binding properties. Incorporating a benz[c,d]indolenine heterocyclic unit increased overall quadruplex binding, and elongating the alkyl length increases the quadruplex-to-duplex binding specificity.

NEAR INFRARED ABSORBING FLUORESCENT COMPOSITIONS

Provided herein are heterocyclic near infrared compounds, including near IR compounds defined by Formulae I-V described herein. The near infrared compounds can include a cyanine group, a phthalocyanine group, a naphthalocyanine group, a squaraine group, a

CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell imaging, cancer cell growth inhibition, and detecting cancer cells, for example. Compounds of the invention are preferentially taken up by cancer cells as compared to normal cells. This allows many uses in the cancer treatment, diagnosis, tracking and imaging fields.

Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents

Protein arginine methylation regulates multiple biological processes. Deregulation of protein arginine methyltransferase (PRMT) activities has been observed in many disease phenotypes. Small molecule probes that target PRMTs with strong affinity and selectivity can be used as valuable tools to dissect biological mechanisms of arginine methylation and establish the role of PRMT proteins in a disease process. In this work, we report synthesis and evaluation of a class of carbocyanine compounds containing indolium, benz[e]indolium or benz[c,d]indolium heterocyclic moieties that bind to the predominant arginine methyltransferase PRMT1 and inhibit its methyltransferase activity at low micromolar potencies. In particular, the developed molecules have long wavelength colorimetric and fluorometric photoactivities, which can be used for optical and near-infrared fluorescence imaging in cells or biological tissues. Together, these new chemical probes have potential application in PRMT studies both as enzyme inhibitors and as fluorescent dyes for microscope imaging.