473416-22-7

Usage

Uses

Used in Pharmaceutical Research and Development:
1H-INDAZOLE-1-CARBOXYLIC ACID,3-BROMO-5-NITRO-,1,1-DIMETHYLETHYL ESTER is used as a key intermediate in the synthesis of pharmaceutical compounds for various therapeutic applications. Its antineoplastic and antimetabolite properties make it a promising candidate for the development of new drugs targeting cancer and other diseases.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1H-INDAZOLE-1-CARBOXYLIC ACID,3-BROMO-5-NITRO-,1,1-DIMETHYLETHYL ESTER is used as a building block for the synthesis of agrochemicals, such as pesticides and herbicides. Its potential antifungal activity contributes to the development of effective solutions for crop protection and disease management.
Used in Anticancer Drug Development:
1H-INDAZOLE-1-CARBOXYLIC ACID,3-BROMO-5-NITRO-,1,1-DIMETHYLETHYL ESTER is used as a precursor in the development of anticancer drugs. Its demonstrated anticancer activity in various studies highlights its potential as a therapeutic agent for the treatment of cancer, particularly when incorporated into novel drug delivery systems to enhance bioavailability and therapeutic outcomes.
Used in Organic Synthesis:
As an ester derivative of 1H-indazole-1-carboxylic acid, 1H-INDAZOLE-1-CARBOXYLIC ACID,3-BROMO-5-NITRO-,1,1-DIMETHYLETHYL ESTER is used in organic synthesis for the preparation of various organic compounds. Its unique structure and functional groups make it a versatile building block for the synthesis of complex organic molecules with potential applications in various fields, including materials science, pharmaceuticals, and agrochemicals.

Upstream product

• 5401-94-5 5-nitroindazole 
• 67400-25-3 3-bromo-5-nitro-1H-indazole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1093061-47-2 (S)-N-(3-(4-fluorophenyl)-1H-indazol-5-yl)-3-(methylthio)-1-(2-oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)-3,6-dihydropyridin-1(2H)-yl)ethyl)pyrrolidine-3-carboxamide 
• 1093063-68-3 C₁₉H₁₉FN₄OS 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS

Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.

Benzo five-membered nitrogen-containing heterocycle derivative and application thereof

The invention relates to a benzo five-membered nitrogen-containing heterocycle derivative. A chemical structure of a compound is shown as the following formula (I) (please see the specifications for the formula (I)); and in the formula (I), X is N or C, Y is C or N, R is 1-methyl-indol-5-yl, 1-methyl-indol-5-yl, 3,4,5-trimethoxyphenyl or p-methylphenyl, and R is 3,4,5-trimethoxyphenyl, p-methylphenyl, 1-methyl-indol-5-yl, 1-methyl-indol-4-yl or 1-methyl-indol-3-yl. The compound can inhibit breeding of tumor cells, and can be used for preparing anti-tumor drugs.

Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology

Compound 5 (SCH772984) was identified as a potent inhibitor of ERK1/2 with excellent selectivity against a panel of kinases (0/231 kinases tested @ 100 nM) and good cell proliferation activity, but suffered from poor PK (rat AUC PK @10 mpk = 0 μM h; F% =

NOVEL 1H-INDAZOLE COMPOUND

The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by -CO-NH- or -NH-CO-, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.