473433-18-0

Basic information

• Product Name: (3R/S,4R,5S)-4-[(tert-butyldiphenylsilyloxy)methyl]-5-(3,4-methylenedioxyphenyl)tetrahydrofuran-3-carboxaldehyde
• Synonyms: (3R/S,4R,5S)-4-[(tert-butyldiphenylsilyloxy)methyl]-5-(3,4-methylenedioxyphenyl)tetrahydrofuran-3-carboxaldehyde
• CAS NO: 473433-18-0
• Molecular Weight: 488.656
• Mol File: 473433-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R/S,4R,5S)-4-[(tert-butyldiphenylsilyloxy)methyl]-5-(3,4-methylenedioxyphenyl)tetrahydrofuran-3-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (3R/S,4R,5S)-4-[(tert-butyldiphenylsilyloxy)methyl]-5-(3,4-methylenedioxyphenyl)tetrahydrofuran-3-carboxaldehyde(473433-18-0)
• EPA Substance Registry System: (3R/S,4R,5S)-4-[(tert-butyldiphenylsilyloxy)methyl]-5-(3,4-methylenedioxyphenyl)tetrahydrofuran-3-carboxaldehyde(473433-18-0)

Safety Data

• Hazardous Substances Data: 473433-18-0(Hazardous Substances Data)

Upstream product

• 473433-15-7 (2R,3R,4S)-3-[(tert-butyldiphenylsilyloxy)methyl]-2-methoxycarbonyl-4-(3,4-methylenedioxyphenyl)-4-butanolide 
• 473433-16-8 (1S,2R)-2-[(tert-butyldiphenylsilyloxy)methyl]-3-hydroxymethyl-1-(3,4-methylenedioxyphenyl)-1,4-butanediol 
• 473433-19-1 (3R,4R,5S)-5-Benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxymethyl-tetrahydro-furan-2-ol 
• 473433-21-5 (4R,5S)-5-Benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-ol 
• 473433-14-6 (3R,4S)-3-[(tert-butyldiphenylsilyloxy)methyl]-4-(3,4-methylenedioxyphenyl)-4-butanolide 
• 195321-29-0 (1S,2R)-1-Benzo[1,3]dioxol-5-yl-2-(tert-butyl-diphenyl-silanyloxymethyl)-pent-4-en-1-ol 
• 473433-17-9 (2S,3R,4R/S)-3-[(tert-butyldiphenylsilyloxy)methyl]-4-hydroxymethyl-2-(3,4-methylenedioxyphenyl)tetrahydrofuran 

Downstream Products

• 189557-98-0 (3S,4R,5S)-5-Benzo[1,3]dioxol-5-yl-4-(tert-butyl-diphenyl-silanyloxymethyl)-3-hydroxy-tetrahydro-furan-3-carbaldehyde 
• 473433-20-4 5-{(2S,3R)-3-(tert-Butyl-diphenyl-silanyloxymethyl)-4-[1-triisopropylsilanyloxy-meth-(Z)-ylidene]-tetrahydro-furan-2-yl}-benzo[1,3]dioxole 

Relevant articles and documents

Synthesis of 1,2-oxygenated 6-arylfurofuran lignan: stereoselective synthesis of (1S,2S,5R,6S)-1-hydroxysamin.

(1S,2S,5R,6S)-6-(3,4-Methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octan-1,2-diol ((+)-1-hydroxysamin 1) was synthesized, starting from olefin 8. Stereoselective alpha-hydroxylation was achieved after converting 8 to aldehyde 13. Resulting unstable alpha-hydroxy aldehyde 14 was then transformed to (+)-1-hydroxysamin (1). This is a new efficient synthetic route to 1,2-oxygenated 6-arylfurofuran lignans.