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N-Benzyloxycarbonyl-2,3-dihydroxypiperidine, also known as 2,3-Dihydroxy-1-piperidinecarboxylic Acid Phenylmethyl Ester (CAS# 473436-50-9), is a chemical compound that plays a significant role in organic synthesis. It is characterized by the presence of a benzyloxycarbonyl group attached to a piperidine ring, which features two hydroxyl groups at the 2nd and 3rd positions. This unique structure endows it with versatile reactivity and potential applications in various fields.

473436-50-9

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473436-50-9 Usage

Uses

Used in Organic Synthesis:
N-Benzyloxycarbonyl-2,3-dihydroxypiperidine is used as a key intermediate in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for selective functionalization and derivatization, making it a valuable building block for the development of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Benzyloxycarbonyl-2,3-dihydroxypiperidine is used as a precursor for the synthesis of bioactive compounds, including drug candidates with potential therapeutic applications. Its ability to form diverse chemical entities makes it a promising starting material for the discovery of new drugs and drug delivery systems.
Used in Agrochemical Industry:
N-Benzyloxycarbonyl-2,3-dihydroxypiperidine also finds applications in the agrochemical industry, where it serves as a precursor for the synthesis of bioactive compounds with pesticidal properties. Its reactivity and structural diversity enable the development of novel agrochemicals with improved efficacy and selectivity.

Check Digit Verification of cas no

The CAS Registry Mumber 473436-50-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,3,4,3 and 6 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 473436-50:
(8*4)+(7*7)+(6*3)+(5*4)+(4*3)+(3*6)+(2*5)+(1*0)=159
159 % 10 = 9
So 473436-50-9 is a valid CAS Registry Number.

473436-50-9Relevant academic research and scientific papers

Concise synthesis of dl-febrifugine

Takeuchi, Yasuo,Oshige, Miyo,Azuma, Kumiko,Abe, Hitoshi,Harayama, Takashi

, p. 868 - 869 (2007/10/03)

Racemic compound (1) of the antimalarial agents febrifugine (d-1) was synthesized using an stereoselective Michael reaction of an ω-amidoenone (5) which was prepared by the Wittig reaction of piperidinediol (7).

Synthesis of febrifugine derivatives and a solution to the puzzle of the structural determination of febrifugine

Takeuchi, Yasuo,Azuma, Kumiko,Oshige, Miyo,Abe, Hitoshi,Nishioka, Hiromi,Sasaki, Kenji,Harayama, Takashi

, p. 1639 - 1646 (2007/10/03)

The stereo-structure of piperidine lactone (3), a synthetic intermediate of the antimalarial agent febrifugine ((+)-1) with a piperidine ring in the trans relative configuration, was re-revised to the cis-form. We determined that isomerization to the trans-form from the cis-form occurred in the stage (6 from 5) of deprotection in Baker's synthesis.

Re-revision of the stereo structure of piperidine lactone, an intermediate in the synthesis of febrifugine.

Takeuchi, Yasuo,Azuma, Kumiko,Abe, Hitoshi,Sasaki, Kenji,Harayama, Takashi

, p. 1011 - 1012 (2007/10/03)

The stereo structure of piperidine lactone (3), an intermediate of the antimalarial agent febrifugine ((+)-1) prepared by a synthetic method, was re-revised to the cis-form from the trans-form.

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