47349-49-5

Basic information

• Product Name: 2-amino-9-(5-O-phosphono-beta-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one
• Synonyms: 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(5-O-phosphono-β-D-xylofuranosyl)-
• CAS NO: 47349-49-5
• Molecular Formula: C₁₀H₁₄N₅O₈P
• Molecular Weight: 363.2206
• Mol File: 47349-49-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 890.2°C at 760 mmHg
• Flash Point: 492.2°C
• Density: 2.47g/cm³
• Vapor Pressure: 5.16E-34mmHg at 25°C
• Refractive Index: 1.946
• PKA: 1.86±0.10(Predicted)
• CAS DataBase Reference: 2-amino-9-(5-O-phosphono-beta-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-9-(5-O-phosphono-beta-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one(47349-49-5)
• EPA Substance Registry System: 2-amino-9-(5-O-phosphono-beta-D-xylofuranosyl)-3,9-dihydro-6H-purin-6-one(47349-49-5)

Safety Data

• Hazardous Substances Data: 47349-49-5(Hazardous Substances Data)

Relevant articles and documents

Synthesis and anti DNA virus activity of the 5' monophosphate and the cyclic 3',5' monophosphate of 9 (β D xylofuranosyl)guanine

9 (β D Xylofuranosyl)guanine (xylo G) was converted chemically to the 9 (β D xylofuranosyl)guanine 5' monophosphate (xylo GMP) and 9 (β D xylofuranosyl)guanine cyclic 3',5' monophosphate (c xylo GMP). These compounds were tested against a variety of DNA viruses in tissue culture in parallel with 9 D arabinofuranosyl)adenine Darabinofuranosyl)adenine (ara A). This evaluation revealed that xylo G, xylo GMP, and c xylo GMP were all moderately active but less effective than ara A. When the four compounds were administered intracerebrally as a treatment for herpes virus, type 1 induced encephalitis in mice, c xylo GMP exhibited superior activity to that shown by the other three. When administered intraperitoneally, c xylo GMP was found to have a therapeutic index of about 4, which is less than that for ara A (30) in the same system.