473530-03-9

Upstream product

• 911-40-0 7-ketodeoxycholic acid 

Downstream Products

• 473529-82-7 N-allyl-N-methyl-3β,12β-bis((2-naphthyl)carbamoyloxy)-7β-(3,5-dinitrophenylcarbamoyl)oxy-5β-cholan-24-amide 
• 874212-70-1 Acetic acid (3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-3-(allyl-methyl-carbamoyl)-1-methyl-propyl]-12-(3,5-dinitro-phenylcarbamoyloxy)-10,13-dimethyl-7-(naphthalen-2-ylcarbamoyloxy)-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 874212-69-8 N-allyl-N-methyl-3-hydroxy-7-(2-naphthyl)carbamoyloxy-12-(3,5-dinitriphenyl)carbamoyloxycholan-24-amide 
• 874212-72-3 Acetic acid (3R,5R,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-3-(allyl-methyl-carbamoyl)-1-methyl-propyl]-12-(3,5-dinitro-phenylcarbamoyloxy)-7-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 874212-74-5 Acetic acid (3R,5S,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-3-(allyl-methyl-carbamoyl)-1-methyl-propyl]-12-(3,5-dinitro-phenylcarbamoyloxy)-10,13-dimethyl-7-oxo-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 

Relevant academic research and scientific papers

Synthesis of four cholic acid-based CSPs containing 2-naphthoyl carbamate and 3,5-dinitrophenylcarbamate moieties and their evaluation in the HPLC resolution of racemic compounds

Four new chiral selectors, obtained by derivatising the hydroxy groups of cholic acid with 2-naphthylisocyanate and 3,5-dinitrophenylisocyanate have been prepared and linked to silica gel to obtain new chiral stationary phases (CSPs) for the HPLC separation of enantiomers. The CSP containing only 2-naphthylcarbamate groups is able to separate the enantiomers of π-acidic substrates, whereas the CSPs containing one 3,5-dinitrophenylcarbamate group and two 2-naphthyl carbamate moieties resolve π-acidic racemic compounds as well as π-basic substrates, with the observed enantiodiscriminating capabilities depending on the arrangement of the different carbamoyl units on the cholestanic backbone.