473530-10-8

Basic information

• Product Name: 3-(morpholine-4-sulphonylmethyl)-5-phenyl-1,2,4-triazine
• Synonyms: 3-(morpholine-4-sulphonylmethyl)-5-phenyl-1,2,4-triazine
• CAS NO: 473530-10-8
• Molecular Weight: 320.372
• Mol File: 473530-10-8.mol

Chemical Properties

• CAS DataBase Reference: 3-(morpholine-4-sulphonylmethyl)-5-phenyl-1,2,4-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(morpholine-4-sulphonylmethyl)-5-phenyl-1,2,4-triazine(473530-10-8)
• EPA Substance Registry System: 3-(morpholine-4-sulphonylmethyl)-5-phenyl-1,2,4-triazine(473530-10-8)

Safety Data

• Hazardous Substances Data: 473530-10-8(Hazardous Substances Data)

Upstream product

• 18162-28-2 5-phenyl-1,2,4-triazine 
• 39542-27-3 4-chloromethanesulfonyl-morpholine 

Downstream Products

• 473530-16-4 3-[1-(morpholine-4-sulphonyl)-hex-5-ynyl]-5-phenyl-1,2,4-triazine 

Relevant articles and documents

Tandem vicarious nucleophilic substitution of hydrogen/intramolecular Diels-Alder reaction of 1,2,4-triazines into functionalized cycloalkenopyridines1

Synthesis of 2,3- and 3,4-cyclopentenopyridines, 5,6,7,8- tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines from 1,2,4-triazine derivatives is reported. Introduction of an α-functionalized methyl substituent (e.g. arylsulphonyl, sulphonamide, sulphonic acid ester) into position 3- or 6- of triazines by vicarious nucleophilic substitution of hydrogen and subsequent alkylation with alkyl iodides bearing an acetylenic function in terminal position afforded valuable intermediates for intramolecular Diels-Alder reaction with inverse electron demand. When heated at higher temperature, these triazine derivatives gave the Diels-Alder cycloadducts, which, after spontaneous extrusion of nitrogen moiety, led to a variety of functionalized cycloalkenopyridine derivatives.