473536-19-5

Upstream product

• 873-67-6 benzonitrile oxide 

Downstream Products

• 119897-89-1 (R)-3-phenyl-Δ²-isoxazoline-5-methanol 
• 17647-39-1 (R)-methyl 3-phenyl-4,5-dihydroisoxazole-5-carboxylate 
• 145-13-1 Pregnenolone 
• 147721-20-8 (R)-3-Phenyl-4,5-dihydro-isoxazole-5-carboxylic acid 

Relevant academic research and scientific papers

Regio- and stereoselective synthesis of isoxazolines via cycloaddition reactions using pregnenolone as chiral auxiliary

The asymmetric 1,3-dipolar cycloaddition reaction of nitrile oxides 2a-b to olefins 1a-c has been acccomplished by employing pregnenolone as chiral auxiliary. The optically pure 3-aryl-5-isoxazoline esters 9 are obtained from the major diastereomer in good yield.