473538-89-5Relevant academic research and scientific papers
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. in vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists
Woltering, Thomas J.,Wichmann, Jürgen,Goetschi, Erwin,Knoflach, Frédéric,Ballard, Theresa M.,Huwyler, J?rg,Gatti, Silvia
scheme or table, p. 6969 - 6974 (2011/02/22)
This study completes a series of papers devoted to the characterization of the non-competitive mGluR2/3 antagonist properties of 1,3-dihydro-benzo[b][1,4] diazepin-2-one derivatives with particular emphasis on derivatizations compatible with brain penetra
Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists
Woltering, Thomas J.,Wichmann, Juergen,Goetschi, Erwin,Adam, Geo,Kew, James N.C.,Knoflach, Frederic,Ballard, Theresa M.,Huwyler, Joerg,Mutel, Vincent,Gatti, Silvia
, p. 2725 - 2729 (2008/12/21)
A series of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Replacement of the (2-aryl)-ethynyl-moiety in 8-position with smaller less lipophilic substituents produced compounds inhibiting the bin
