473733-16-3

Usage

Uses

Used in Pharmaceutical Industry:
(R)-1-(3,5-DIFLUOROPHENYL)PROPAN-1-AMINE-HCl is used as a selective agonist for the trace amine-associated receptor 1 (TAAR1) for its potential pharmacological effects on the central nervous system. It has shown promise in preclinical studies for the treatment of conditions such as depression, schizophrenia, and substance abuse.
Used in Research and Development:
(R)-1-(3,5-DIFLUOROPHENYL)PROPAN-1-AMINE-HCl is used as a research compound for further investigation into its stereoselectivity and affinity for TAAR1, which can contribute to the development of new therapeutic agents targeting the central nervous system.

Downstream Products

• 473725-99-4 C₂₂H₂₁F₂N₃O₄ 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists

A series of 3,4- and 3,5-disubstituted phenyl-containing cyclobutenedione analogues were synthesized and evaluated as CXCR2 receptor antagonists. Variations in the disubstitution pattern of the phenyl ring afforded new compounds with potent CXCR2 binding

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.