47375-32-6

Upstream product

• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 20299-41-6 (S)-2-Benzyloxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 949-99-5 4-nitro-3-phenyl-L-alanine 
• 501-53-1 benzyl chloroformate 
• 17193-40-7 (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride 
• 142035-73-2 (R,S)-α-benzyloxycarbonylamino-3-(4-nitrophenyl)propionic acid methyl ester 

Downstream Products

• 20299-46-1 4-Bromacetyl-amino-N-carbobenzoxy-phenylalaninmethylester 
• 1427053-75-5 (S)-methyl 3-(4-acrylamidophenyl)-2-(((benzyloxy)methyl)amino)propanoate 
• 1184247-96-8 2-amino-3-[4-(5-phenyl-tetrazol-2-yl)-phenyl]-propionic acid methyl ester 

Relevant academic research and scientific papers

Developing new chemical tools for DNA methyltransferase 1 (DNMT 1): A small-molecule activity-based probe and novel tetrazole-containing inhibitors

DNA methylation is an important epigenetic modification catalyzed by DNA methyltransferases (DNMTs). Abnormal expression of endogenous DNMTs in human causes alterations in the genome methylation patterns which subsequently lead to the development of cance

SAR development of lysine-based irreversible inhibitors of transglutaminase 2 for huntington's disease

We report a series of irreversible transglutaminase 2 inhibitors starting from a known lysine dipeptide bearing an acrylamide warhead. We established new SARs resulting in compounds demonstrating improved potency and better physical and calculated properties. Transglutaminase selectivity profiling and in vitro ADME properties of selected compounds are also reported.