473758-22-4Relevant academic research and scientific papers
Cyclopropanation of protected chiral, acyclic allylic alcohols: Expedient access to the anti-cyclopropylcarbinol derivatives
Charette, Andre B.,Lacasse, Marie-Christine
, p. 3351 - 3353 (2007/10/03)
(matrix presented) The diastereoselective cyclopropanation of silyl-protected chiral allylic alcohols using Shi's carbenoid (TFA-Et2Zn-CH2I2) gave access to the anti-cyclopropylcarbinyl silyl ethers with excellent diastereocontrol. The level of stereocontrol was shown to depend on the sizes of the protective group and the allylic substituent.
