473758-96-2Relevant academic research and scientific papers
Studies in marine macrolide synthesis: Stereocontrolled synthesis of a C21-C34 subunit of the aplyronines
Paterson, Ian,Blakey, Simon B,Cowden, Cameron J
, p. 6005 - 6008 (2002)
The C21-C34 subunit 27 of the aplyronines, containing eight stereocentres and a terminal N-methyl-N-vinylformamide moiety, was prepared using the Horner-Wadsworth-Emmons coupling of β-ketophosphonate 5 with aldehyde 19. The two stereotetrad sequences were constructed by chiral ketone aldol reactions, while the N-methyl-N-vinylformamide was introduced using a novel Wittig olefination.
Total synthesis of auripyrone a using a tandem non-aldol aldol/ paterson aldol process as a key step
Jung, Michael E.,Salehi-Rad, Ramin
supporting information; experimental part, p. 8766 - 8769 (2010/02/27)
To aldol or non-aldol: The titled reaction sequence generates the polypropionate 3 from the epoxy alcohol 1 and the ketone 2 as a single diastereomer. Compound 2 was used for an efficient synthesis of auripyrone A using a highly regioselective hemiketaliz
Structure assignment of lagunapyrone B by fluorous mixture synthesis of four candidate stereoisomers
Yang, Fanglong,Newsome, Jeffery J.,Curran, Dennis P.
, p. 14200 - 14205 (2008/02/10)
Techniques of fluorous mixture synthesis have been used to make four candidate stereoisomers for the natural product lagunapyrone B. A quasiracemic mixture of vinyl iodides whose component configurations at C19-21 were encoded by fluorous silyl groups was
