47377-38-8Relevant academic research and scientific papers
Microwave-assisted copper(I) catalyzed A3-coupling reaction: Reactivity, substrate scope and the structural characterization of two coupling products
Kashid, Vitthalrao S.,Balakrishna, Maravanji S.
, p. 78 - 82 (2017/10/13)
The application of highly efficient catalyst [{Cu(μ ? I)2Cu}(PPh3)4] for the synthesis of biologically and pharmaceutically important propargylamine derivatives through microwave assisted A3-coupling reaction is
Efficient one-pot synthesis of propargylamines from Mannich bases through a retro-Mannich-type fragmentation
Zhu, Yefeng,Zhao, Huishuang,Wei, Yunyang
, p. 952 - 958 (2013/05/09)
An efficient one-pot synthesis of propargylamines is achieved by copper-catalyzed coupling of phenylacetylenes with Mannich bases through a chlorine(1+) or bromine(1+) ion-initiated retro-Mannich-type fragmentation under mild conditions. The Mannich bases are easily prepared from an electron-rich phenol, formaldehyde, and an amine. The protocol provides an appealing alternative for the construction of propargylamines by a simple one-pot procedure. Georg Thieme Verlag Stuttgart - New York.
