473919-62-9Relevant academic research and scientific papers
Pyrazole NNRTIs 3: Optimisation of physicochemical properties
Mowbray, Charles E.,Corbau, Romuald,Hawes, Michael,Jones, Lyn H.,Mills, James E.,Perros, Manos,Selby, Matthew D.,Stupple, Paul A.,Webster, Rob,Wood, Anthony
scheme or table, p. 5603 - 5606 (2010/04/05)
Our efforts to reduce overall lipophilicity and increase ligand-lipophilicity efficiency (LLE) by modification of the 3- and 5-substituents of pyrazole 1, a novel non-nucleoside HIV reverse transcriptase inhibitor (NNRTI) prototype were unsuccessful. In c
