473969-01-6

Basic information

• Product Name: (1S,3R,5R)-3-Benzo[b]thiophen-3-yl-8-benzyl-8-aza-bicyclo[3.2.1]octan-3-ol
• CAS NO: 473969-01-6
• Molecular Weight: 349.497
• Mol File: 473969-01-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,3R,5R)-3-Benzo[b]thiophen-3-yl-8-benzyl-8-aza-bicyclo[3.2.1]octan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3R,5R)-3-Benzo[b]thiophen-3-yl-8-benzyl-8-aza-bicyclo[3.2.1]octan-3-ol(473969-01-6)
• EPA Substance Registry System: (1S,3R,5R)-3-Benzo[b]thiophen-3-yl-8-benzyl-8-aza-bicyclo[3.2.1]octan-3-ol(473969-01-6)

Safety Data

• Hazardous Substances Data: 473969-01-6(Hazardous Substances Data)

Upstream product

• 28957-72-4 N-benzyltropinone 
• 20896-16-6 3-lithiobenzothiophene 
• 5632-84-8 nortropinone 
• 532-24-1 tropinone 

Relevant articles and documents

Modulation of selective serotonin reuptake inhibitor and 5-HT1A antagonist activity in 8-aza-bicyclo[3.2.1]octane derivatives of 2,3-dihydro-1,4-benzodioxane

2,3-Dihydro-1,4-benzodioxanes with aryl 8-aza-bicyclo[3.2.1]oct-3-ene attachments 2 produce compounds with potent 5-HT-T affinity, and weak 5-HT 1A affinity and α1 affinity. This compares with 2,3-dihydro-1,4-benzodioxanes containing 8-aza-bicyclo[3.2.1] octan-3-ol attachments 4 which possess potent 5-HT1A affinity, moderate to good selectivity over α1 and little 5-HT-T affinity. A 3-benzothiophene analogue of 4 (30) was synthesized which possesses potent 5-HT1A affinity and especially good selectivity over both α1 and 5-HT-T.