474-77-1

Usage

Uses

Used in Pharmaceutical Industry:
EPICHOLESTEROL is used as a target for drug development for the regulation of cholesterol levels in the body. Its influence on the activity of enzymes involved in cholesterol synthesis makes it a promising candidate for the development of new therapies for conditions related to cholesterol metabolism and associated diseases.
Used in Research:
EPICHOLESTEROL is used as a subject of research in the field of lipid metabolism to gain valuable insights into the development of new therapies for conditions related to cholesterol metabolism and associated diseases. Further research on EPICHOLESTEROL may contribute to a better understanding of cholesterol regulation and the discovery of novel treatment options.

InChI:InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21-,22+,23-,24+,25+,26+,27-/m1/s1

Upstream product

• 60-29-7 diethyl ether 
• 2309-32-2 3-acetoxy-cholesta-3,5-diene 
• 76514-42-6 {2-[(3S,8S,9S,10R,13R,14S)-17-((R)-1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxymethoxy]-ethyl}-trimethyl-silane 
• 2203-80-7 5-methylhex-1-yne 

Downstream Products

• 6252-45-5 Cholesterol-3-tetrahydropyranylether 
• 2930-80-5 17-(1,5-Dimethyl-hexyl)-3-iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene 
• 1856-05-9 Trimethylsilylaether von Cholesterol 
• 601-54-7 cholest-5-en-3-one 
• 1510-21-0 5-cholesten-3β-ol 3-(3-carboxypropanoate) 
• 566-28-9 3β-Hydroxycholest-5-en-7-on 
• 566-26-7 Cholest-5-ene-3α,7α-diol 
• 3381-54-2 Cholesteryl-methansulfonat 
• 712349-49-0 N',N''-dicyclohexyl-N-furfuryl-guanidyno(ferrocenyl)methane phosphonous acid 
• 100102-45-2 3,4,6-tri-O-benzoyl-1,2-O-cholesterylorthobenzoyl-α-D-glucopyranose 

Relevant academic research and scientific papers

STEREOCONTROLLED SYNTHESIS OF STEROID SIDE CHAIN; STEREOSELECTIVE SYNTHESES OF CHOLESTEROL AND 25-HYDROXYCHOLESTEROL

Novel stereoselective method to introduce side chain onto 17-oxosteroids has been deviced, and using the method cholesterol and 25-hydroxycholesterol are synthesized.

β-(Trimethylsilyl)ethoxymethyl chloride. A new reagent for the protection of the hydroxyl group

Reactions of β-(trimethylsilyl)ethoxymethyl chloride with alcohols afford the corresponding ethers in high yield. Deprotection using n-Bu4NF in THF or HMPA cleanly regenerates the hydroxyl function.

Synthesis of steroids

In the synthesis of sterols wherein methoxyethoxymethyl groups in an ether linkage are attached to the nucleus of the sterol to protect the sterol nucleus during other steps of the synthesis and the sterols are thereafter treated to remove the methoxyethoxymethyl groups and set free the hydroxyl groups, the improvement in which the sterols being treated with zinc bromide are held in a methylene chloride solution containing a small amount of an aliphatic alcohol having from 1 to 6 carbon atoms.