474010-01-0

Basic information

• Product Name: Morpholine, 4-[(2R)-2-[[(4-methylphenyl)sulfonyl]oxy]-1-oxopropyl]-
• CAS NO: 474010-01-0
• Molecular Formula: C14H19NO5S
• Molecular Weight: 313.375
• Mol File: 474010-01-0.mol

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[(2R)-2-[[(4-methylphenyl)sulfonyl]oxy]-1-oxopropyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[(2R)-2-[[(4-methylphenyl)sulfonyl]oxy]-1-oxopropyl]-(474010-01-0)
• EPA Substance Registry System: Morpholine, 4-[(2R)-2-[[(4-methylphenyl)sulfonyl]oxy]-1-oxopropyl]-(474010-01-0)

Safety Data

• Hazardous Substances Data: 474010-01-0(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 135206-87-0 (2R)-1-morpholin-4-yl-1-oxopropane-2-ol 

Downstream Products

• 502481-62-1 2-((S)-1-morpholinocarbonylethoxy)-4-hydroxymethylnitrobenzene 
• 502481-65-4 methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate 
• 502481-63-2 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylnitrobenzene 
• 502481-64-3 2-((S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylaniline 

Relevant articles and documents

INDOLE, INDAZOLE, AND BENZAZOLE DERIVATIVE

The compound of the formula (I): wherein W is a group of the following formula (VIII) binding to any possible position on the Q: Q is, together with W, a group of the formula: -C(M=C(R3A)-N(R3)-, etc.; R3A is H or optionally substituted lower alkyl; R4, R5, R6, and R7 are independently H or optionally substituted lower alkyl; R1 is optionally substituted lower alkyl, etc.; R2 is H, etc.; R3 is H, etc.; Ar is phenyl, etc., or a pharmaceutically acceptable salt thereof, where these compounds exhibiting β3-adrenoceptor-stimulating activity and being useful as a medicament for treatment of obesity, etc.

PYRROLE DERIVATIVE

A novel pyrrole derivative represented by the following formula (1) and a salt thereof: wherein R1 means substituted alkenyl, etc.; R2 means substituted benzoyl, etc.; and R3 to R5 each means hydrogen, alkyl, halogeno, etc. The derivative and salt have antidiabetic activity.

Tricyclic indole-2-carboxylic acids: Highly in vivo active and selective antagonists for the glycine binding site of the NMDA receptor

A series of tricyclic indole-2-carboxylic acid derivatives were synthesized and evaluated by the radioligand binding assay and the anticonvulsant effects in the mouse NMDA-induced seizure model. Among them, derivatives of 3S-(-)-4 such as 3a, 3f, and 3g which had certain zwitterionic anilides showed high affinity to the NMDA-glycine binding site. The absolute configuration of 3S-(-)-4 was confirmed by X-ray crystallographic analysis. In particular, 3g (SM-31900) was found to be a highly active glycine antagonist for both in vitro and in vivo assays (Ki = 1.0 ± 0.1 nM, ED50 = 2.3 mg/kg, iv) and also showed high selectivity for the glycine site. In addition, 3g was soluble enough in aqueous media (> 10 mg/mL at pH 7.4) to use for medications by intravenous injection.