474095-65-3

Upstream product

• 474095-64-2 [(1R,2R)-1-((S)-2-Benzyloxy-1-methyl-ethyl)-2-methyl-but-3-enyloxy]-tert-butyl-dimethyl-silane 
• 74924-27-9 methyl (S)-3-benzyloxy-2-methylpropanoate 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 79027-28-4 (2S)-3-(benzyloxy)-2-methylpropanal 
• 63930-49-4 (R)-3-(benzyloxy)-2-methylpropan-1-ol 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 167842-08-2 (2S,3S,4S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2,4-dimethylpentanal 

Relevant academic research and scientific papers

Asymmetric catalysis route to anti,anti stereotriads, illustrated by applications

(Chemical Equation Presented) A short sequence based on asymmetric catalysis, chirality transfer, and an optimized carbometallation protocol gave an anti,anti stereotriad building block in six steps. Both enantiomers of the chirality source, N-methyl ephedrine, are inexpensive, and the auxiliary is recoverable. In one chiral series, the building block was converted to the B-2 intermediate in Miyashita's synthesis of scytophycin C; in the enantiomeric series, it was converted to a key intermediate for aplyronine A and to the polyketide cap for the callipeltins.

Stereoselective synthesis of (2R,3R,4R)-3-hydroxy-2,4,6-trimethylheptanoic acid and determination of the absolute stereochemistry of the natural product from callipeltin A

A revised stereostructure of 3-hydroxy-2,4,6-trimethylheptanoic acid, the β-hydroxy acid that acylates the N-terminus of callipeltin A, is proposed on the basis of analysis of J-coupling in the 1H NMR spectrum of the acetonide derivative obtain