474099-95-1Relevant articles and documents
A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-{4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)-2R, 6S-dimethylpiperazin-1-yl]pyrimidin-2-yl}ethanol
Mylari, Banavara L.,Oates, Peter J.,Zembrowski, William J.,Beebe, David A.,Conn, Edward L.,Coutcher, James B.,O'Gorman, Melissa T.,Linhares, Michael C.,Withbroe, Gregory J.
, p. 4398 - 4401 (2002)
We report here a novel sorbitol dehydrogenase inhibitor, 16, that shows very high oral potency (50 μg/kg) in normalizing elevated fructose levels in the sciatic nerve of chronically diabetic rats and sustained duration of action (>24 h). Furthermore, 16 s