474103-29-2

Upstream product

• 175140-75-7 (4,6-dichloro-2-methyl-pyrimidin-5-yl)-acetic acid ethyl ester 
• 7459-46-3 triethyl 1,1,2-ethanetricarboxylate 
• 474103-26-9 {5-[1-(tert-butyl-dimethyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-amine 
• 474103-24-7 5-[1-(tert-butyl-dimethyl-silanyloxymethyl)-but-3-enyl]-4,6-dichloro-2-methyl-pyrimidine 
• 474103-23-6 2-(4,6-dichloro-2-methyl-pyrimidin-5-yl)-pent-4-en-1-ol 
• 474103-28-1 {5-[1-(tert-butyl-dimethyl-silanyloxymethyl)-but-3-enyl]-6-chloro-2-methyl-pyrimidin-4-yl}-(2,4-dichloro-phenyl)-carbamic acid tert-butyl ester 

Downstream Products

• 474103-32-7 [4-chloro-7-(2,4-dichloro-phenyl)-2-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-5-yl]-acetaldehyde 
• 474103-31-6 5-allyl-4-chloro-7-(2,4-dichloro-phenyl)-2-methyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 
• 474103-30-5 methanesulfonic acid 2-{4-[tert-butoxycarbonyl-(2,4-dichloro-phenyl)-amino]-6-chloro-2-methyl-pyrimidin-5-yl}-pent-4-enyl ester 

Relevant academic research and scientific papers

Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety

Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented.