474104-33-1

Upstream product

• 56441-85-1 4-(2,4-Dichlorbenzyloxy)-benzoesaeureaethylester 
• 120-47-8 Ethyl 4-hydroxybenzoate 
• 94-99-5 2,4-Dichlorobenzyl chloride 
• 99-76-3 methyl 4-hydroxylbenzoate 

Downstream Products

• 947264-06-4 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-4-amino-5-mercapto-1,2,4-triazole 
• 1419966-23-6 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole-6(5H)-thione 
• 1419966-51-0 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-6-phenyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole 
• 1419966-80-5 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-6,7-diphenyl-5H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 
• 1419967-08-0 6-phenyl-3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine 
• 1419967-37-5 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-6-aminophenyl-5H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole 
• 1419967-65-9 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole 
• 1419967-93-3 3-{4'-(2'',4''-dichlorobenzyloxy)-phenyl}-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazine-6(5H)-one 
• 1426953-81-2 C₁₆H₁₂Cl₂N₂O₂S 
• 1426953-83-4 C₂₂H₁₆Cl₂N₂O₂S 
• 1426953-84-5 C₂₂H₁₅Cl₃N₂O₂S 
• 1426953-85-6 C₂₂H₁₄Cl₄N₂O₂S 
• 1426953-86-7 C₂₁H₁₂Cl₂N₄O₆S 
• 1426953-87-8 C₁₆H₁₂Cl₂N₂O₂S 

Relevant academic research and scientific papers

Synthesis and antifungal activity of 1-aminomethyl-3-{4- (chlorobenzyloxy) benzoylhydrazono}-4, 5/5, 6-dichloroindolin-2- ones

3-{4-(Chlorobenzyloxy) benzoylhydrazono}-4,5/5,6-dichloroindolin-2-ones 1a,b-5a,b, were synthesized by the condensation of 4-(chlorobenzyloxy) benzoylhydrazines and 4, 5/5, 6-dichloroindolin-2,3-diones. Compounds 1a,b-5a,b when subjected to Mannich reaction with secondary heterocyclic amines in the presence of formaldehyde, furnished 1-aminomethyl-3-{4-(chlorobenzyloxy) benzoylhydrazono}-4, 5/5, 6-dichloroindolin-2- ones 6a,b-20a,b. The structures of the compounds have been established by means of spectral (IR and 1H NMR) and elemental analysis. The compounds have been screened for their antifungal potential against human pathogenic fungi.

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.