47415-89-4Relevant academic research and scientific papers
Racemic prostaglandins of the 2-series and analogs thereof
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, (2008/06/13)
This invention is racemic PGE2, racemic PGF2α, racemic PGF2β , racemic PGA2, racemic PGB2, analogs of those, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including anti-ulcer, inhibition of platelet aggregation, increase of nasal patency, abortion, and wound healing.
8β-PGE2 and related compounds
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, (2008/06/13)
This invention is a group of compounds of the formula: SPC1 Wherein R1 is hydrogen, alkyl of one to 8 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one to 3 chloro, or alkyl of one to 4 carbon atoms, inclusive, or ethyl substituted in the β-position with 3 chloro, 2 or 3 bromo, or 1, 2, or 3 iodo; wherein R2 is hydrogen or alkyl of one to 10 carbon atoms, inclusive, substituted with zero to 3 fluoro; wherein R3 and R4 are hydrogen or alkyl of one to 4 carbon atoms, inclusive; wherein A is alkylene of one to 10 carbon atoms, inclusive, substituted with zero to 2 fluoro, and with one to 5 carbon atoms, inclusive, between --COOR1 and EQU1 and pharmacologically acceptable salts thereof when R1 is hydrogen. These compounds are useful for a variety of pharmacological purposes, including lowering of blood pressure, control of the mammalian reproductive cycle, and increase of nasal patency.
