474267-23-7

Upstream product

• 119910-45-1 2-bromo-1H-indole-3-carbaldehyde 
• 536-74-3 phenylacetylene 
• 3757-88-8 tributylstannylethynylbenzene 

Downstream Products

• 129410-26-0 methyl 2-phenyl-9H-carbazole-3-carboxylate 
• 1350934-42-7 2-(2-oxo-2-phenylethyl)-1H-indole-3-carbaldehyde 

Relevant academic research and scientific papers

Metal-Free Carbonyl-Assisted Regioselective Hydration of Alkynes: An Access to Dicarbonyls

Metal-free regioselective hydration of o-alkynylaldehydes with the assistance of neighboring carbonyl oxygen is disclosed. The developed protocol provides a facile route to synthesize a series of multisubstituted carbonyl containing scaffolds that enable

Transition-Metal-Free Access to Pyridocarbazoles from 2-Alkynylindole-3-carbaldehydes via Azomethine Ylide

An efficient approach for the synthesis of functionalized tetrahydro-pyrido/quinolinocarbazoles from 2-alkynylindole-3-carbaldehydes and l-proline utilizing a metal-free decarboxylative cyclization, ring expansion, and ring contraction strategy via the ge

Design, synthesis and cytotoxicity of pyrano[4,3-b]indol-1(5H)-ones: A hybrid pharmacophore approach via gold catalyzed cyclization

Reported herein is the gold(III)-catalyzed 6-endo-dig cycloisomerization of 2-alkynyl-indole-3-carboxylic acids to form pyrano[4,3-b]indol-1(5H)-ones, which are pharmaceutically important structural motifs. The hitherto unknown substrates required for thi

Novel synthetic method of 2-(2-oxoethyl)-1 H -indole-3-carbaldehydes

The smooth and regioselective synthesis of 2-(2-oxo-ethyl)-1H-indole-3- carbaldehydes via silver-catalyzed 6-endo-dig acetalization-cyclization reaction followed by immediate hydrolysis of the unstable 1-alkoxypyrano[4,3-b]indole intermediates is describe

Rapid access to benzo-annelated heterocycles, naphthalenes, and polysubstituted benzenes through a novel benzannulation reaction

A novel, efficient, and powerful methyl mercaptoacetate triggered benzannulation reaction is described. The precursors are heterocyclic, aromatic or acyclic compounds bearing a carbonyl group at ortho position to an internal alkyne. The methodology does not require transition-metal catalysts and moreover it is general for the preparation of wide range of benzo-annelated heterocycles, naphthalenes and benzenes.

Indole derivatives for use as chemical uncoupler

Novel 3-vinylsulfonyl indole derivatives are chemical uncouplers useful e.g. for treatment of obesity.

INDOLE DERIVATIVES FOR USE AS CHEMICAL UNCOUPLER

Novel 3-vinylsulfonyl indole derivatives of formula (I) are chemical uncouplers useful e.g. for treatment of obesity.

Synthesis of β- and γ-carbolines by the palladium/copper-catalyzed coupling and cyclization of terminal acetylenes

A variety of 3-substituted β- and γ-carbolines have been synthesized from N-substituted 3-iodoindole-2-carboxaldehydes and 2-bromoindole-3-carboxaldehydes, respectively. The coupling of these aldehydes with various terminal acetylenes with PdCl2(PPh3)2/CuI as the catalyst readily affords the corresponding alkynylindole carboxaldehydes, which have subsequently been converted to the corresponding tert-butylimines and cyclized to β- and γ-carbolines by either copper-catalyzed or thermal processes.