474329-18-5

Upstream product

• 141436-58-0 (-)-(1R)-1-[(4R,5S)-5-((1S)-1-hydroxyallyl)-2,2-dimethyl[1,3]dioxolan-4-yl]ethane-1,2-diol 
• 474329-16-3 (-)-(1S)-1-[(4S,5S)-5-(hydroxymethyl)-2,2-dimethyl-5-vinyl[1,3]dioxolan-4-yl]prop-2-en-1-ol 
• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 76-83-5 trityl chloride 
• 474329-17-4 (+)-(3aS,4S,6aS)-6a-hydroxymethyl-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol 

Downstream Products

• 474329-19-6 methanesulfonic acid (3aS,4S,6aS)-2,2-dimethyl-6a-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl ester 
• 857896-69-6 (+)-(1aR,1bS,4aS,5S,5aS)-3,3-dimethyl-1b-trityloxymethylhexahydro-2,4-dioxacyclopropa[a]pentalen-5-ol 
• 661463-51-0 6-chloro-9-[(3aS,4S,6aS)-2,2-dimethyl-6a-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl]-9H-purine 
• 1067235-57-7 C₃₃H₂₈Cl₂N₄O₃ 
• 857896-70-9 (+)-6-chloro-9-((1aR,1bS,4aS,5R,5aS)-3,3-dimethyl-1b-trityloxymethylhexahydro-2,4-dioxacyclopropa[a]pentalen-5-yl)-9H-purine 
• 857896-71-0 (+)-(1aR,1bS,4aS,5R,5aS)-9-(3,3-dimethyl-1b-trityloxymethylhexahydro-2,4-dioxacyclopropa[a]pentalen-5-yl)-9H-purin-6-ylamine 
• 474329-20-9 9-[(3aS,4R,6aS)-2,2-dimethyl-6a-trityloxymethyl-4,6-a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl]-9H-purin-6-ylamine 
• 661463-47-4 [9-(2,2-dimethyl-6a-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl)-9H-purin-6-yl]-methyl-amine 
• 857896-63-0 N-[6-chloro-9-[(3aS,4S,6aS)-2,2-dimethyl-6a-trityloxymethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-yl]-9H-purin-2-yl]acetamide 

Relevant academic research and scientific papers

Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A

A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrola

Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor

(matrix presented) A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potencial inhibitor of S-adenosylhomocysteine hydrolase, ws accomplished starting from D-ribose via stereoselective hydroxyme

Asymmetric synthesis of novel apio carbocyclic nucleoside analogues as potential antiviral and antitumor agent

Novel apio carbocyclic nucleosides 18-21 were asymmetrically synthesized as potential antiviral and antitumor agent, starting from D-ribose employing aldol reaction, RCM reaction and Mitsunobu reaction as key reactions. Copyright Taylor & Francis Group, L

Stereoselective synthesis of conformationally rigid apio carbanucleosides as potential antiviral agents

Apio north-methanocarbocyclic nucleosides 1-3 with bicyclo[3.1.0]hexane template were first synthesized. Introduction of hydroxymethyl substituent was efficiently and stereoselectively accomplished by aldol and retro-aldol reaction and fixed conformation

Synthesis of novel apio carbocyclic nucleoside analogues as selective A3 adenosine receptor agonists

On the basis of the biological activity of neplanocin A and apio-dideoxyadenosine (apio-ddA), novel apio-neplanocin A analogues 5a-d, combining the properties of two nucleosides, were stereoselectively synthesized. The apio moiety of the target nucleoside