474352-95-9

Usage

Chemical class

Heterocyclic compound

Explanation

It is a compound that contains a benzene ring fused to a diazocine ring, which are both heterocyclic structures.

Explanation

The compound has a complex molecular structure with various substituents attached to the carbon atoms of the rings.

Explanation

1,5-Benzodiazocin-4(1H)-one, 2,3,5,6-tetrahydrohas been the subject of research and development as a potential drug candidate for various therapeutic applications.

Explanation

The compound has potential applications in different areas of medicine, although specific applications are not mentioned in the material provided.

Explanation

The chemical and pharmacological properties of 1,5-Benzodiazocin-4(1H)-one, 2,3,5,6-tetrahydromake it a subject of interest for further study in the field of medicinal chemistry and drug discovery.

Explanation

The compound is still under investigation, and its potential as a drug candidate is being explored in various research studies.

Molecular structure

Complex

Pharmacological properties

Potential

Therapeutic applications

Various

Field of interest

Medicinal chemistry and drug discovery

Research status

Ongoing

Upstream product

• 930-21-2 2-azetidinone 
• 3959-05-5 2-bromobenzylamine 

Relevant academic research and scientific papers

Synthesis of Medium Ring Nitrogen Heterocycles via a Tandem Copper-Catalyzed C-N Bond Formation-Ring-Expansion Process

A simple method for the preparation of medium ring heterocycles (7-, 8-, 9-, and 10-membered) has been developed. The process employs a Cu-catalyzed coupling of a β-lactam with an aryl bromide or iodide followed by intramolecular attack of a pendant amino group. In some instances, the intermediate β-lactam is observable but can be converted to the aza-heterocycle by catalysis. Acetic acid was found to be superior to transition metal complexes as a catalyst for this ring-expansion process.

Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds

The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.